Gene Review:
TP53BP1 - tumor protein p53 binding protein 1
Homo sapiens
Synonyms:
53BP1, Tumor suppressor p53-binding protein 1, p202, p53-binding protein 1, p53BP1
- p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder. Grand, F.H., Burgstaller, S., Kühr, T., Baxter, E.J., Webersinke, G., Thaler, J., Chase, A.J., Cross, N.C. Cancer Res. (2004)
- Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. Rappold, I., Iwabuchi, K., Date, T., Chen, J. J. Cell Biol. (2001)
- p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. Schultz, L.B., Chehab, N.H., Malikzay, A., Halazonetis, T.D. J. Cell Biol. (2000)
- P202, an interferon-inducible protein, inhibits E2F1-mediated apoptosis in prostate cancer cells. Yan, D.H., Abramian, A., Li, Z., Ding, Y., Wen, Y., Liu, T.J., Hunt, K. Biochem. Biophys. Res. Commun. (2003)
- A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Zhang, D., Zaugg, K., Mak, T.W., Elledge, S.J. Cell (2006)
- Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair. Botuyan, M.V., Lee, J., Ward, I.M., Kim, J.E., Thompson, J.R., Chen, J., Mer, G. Cell (2006)
- MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Dimitrova, N., de Lange, T. Genes Dev. (2006)
- Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Joo, W.S., Jeffrey, P.D., Cantor, S.B., Finnin, M.S., Livingston, D.M., Pavletich, N.P. Genes Dev. (2002)
- TP53-binding protein variants and breast cancer risk: a case-control study. Frank, B., Hemminki, K., Bermejo, J.L., Klaes, R., Bugert, P., Wappenschmidt, B., Schmutzler, R.K., Burwinkel, B. Breast Cancer Res. (2005)
- Prostate-specific antitumor activity by probasin promoter-directed p202 expression. Wen, Y., Giri, D., Yan, D.H., Spohn, B., Zinner, R.G., Xia, W., Thompson, T.C., Matusik, R.J., Hung, M.C. Mol. Carcinog. (2003)
- The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation. Lo, K.W., Kan, H.M., Chan, L.N., Xu, W.G., Wang, K.P., Wu, Z., Sheng, M., Zhang, M. J. Biol. Chem. (2005)
- 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. DiTullio, R.A., Mochan, T.A., Venere, M., Bartkova, J., Sehested, M., Bartek, J., Halazonetis, T.D. Nat. Cell Biol. (2002)
- E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts. Frame, F.M., Rogoff, H.A., Pickering, M.T., Cress, W.D., Kowalik, T.F. Oncogene (2006)
- The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity. Boisvert, F.M., Rhie, A., Richard, S., Doherty, A.J. Cell Cycle (2005)
- Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. Kao, G.D., McKenna, W.G., Guenther, M.G., Muschel, R.J., Lazar, M.A., Yen, T.J. J. Cell Biol. (2003)
- Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1(-/-) B cells. Reina-San-Martin, B., Chen, J., Nussenzweig, A., Nussenzweig, M.C. Eur. J. Immunol. (2007)
- Microwaves from GSM mobile telephones affect 53BP1 and gamma-H2AX foci in human lymphocytes from hypersensitive and healthy persons. Markovà, E., Hillert, L., Malmgren, L., Persson, B.R., Belyaev, I.Y. Environ. Health Perspect. (2005)
- The expression of the MDM2 gene, a p53 binding protein, in thyroid carcinogenesis. Zou, M., Shi, Y., al-Sedairy, S., Hussain, S.S., Farid, N.R. Cancer (1995)
- p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. Datta, B., Li, B., Choubey, D., Nallur, G., Lengyel, P. J. Biol. Chem. (1996)
- Jun activation domain-binding protein 1 is required for mitotic checkpoint activation via its involvement in hyperphosphorylation of 53BP1. Kwak, H.J., Kim, S.H., Yoo, H.G., Park, S.H., Lee, C.H. J. Cancer Res. Clin. Oncol. (2005)
- Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2. Thukral, S.K., Blain, G.C., Chang, K.K., Fields, S. Mol. Cell. Biol. (1994)
- The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage. Eliezer, Y., Argaman, L., Rhie, A., Doherty, A.J., Goldberg, M. J. Biol. Chem. (2009)
- Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. Ward, I.M., Minn, K., Jorda, K.G., Chen, J. J. Biol. Chem. (2003)
- Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Chan, D.W., Chen, B.P., Prithivirajsingh, S., Kurimasa, A., Story, M.D., Qin, J., Chen, D.J. Genes Dev. (2002)
- Inhibition of E2F-4/DP-1-stimulated transcription by p202. Choubey, D., Gutterman, J.U. Oncogene (1997)
- The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. Hsu, H.L., Shi, B., Gartenhaus, R.B. Oncogene (2005)
- NFBD1/Mdc1 mediates ATR-dependent DNA damage response. Peng, A., Chen, P.L. Cancer Res. (2005)
- Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck. Chen, K., Hu, Z., Wang, L.E., Zhang, W., El-Naggar, A.K., Sturgis, E.M., Wei, Q. Clin. Cancer Res. (2007)
- hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage. Richie, C.T., Peterson, C., Lu, T., Hittelman, W.N., Carpenter, P.B., Legerski, R.J. Mol. Cell. Biol. (2002)
- NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. Peng, A., Chen, P.L. J. Biol. Chem. (2003)
- Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor. Derbyshire, D.J., Basu, B.P., Date, T., Iwabuchi, K., Doherty, A.J. Acta Crystallogr. D Biol. Crystallogr. (2002)