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Gene Review:

MIXL1 - Mix paired-like homeobox

Gallus gallus

Stein, S. et al., Peale, F.V. et al., Shiraki, N. et al., Roeser, T. et al., Pearce, J.J. et al.

Pearce, Evans, Peale, Sugden, Bothwell,

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High impact information on CMIX

Embryos treated before primitive streak formation become completely radialized, as shown by the expression of molecular markers, CMIX and GSC [1].
Co-cultivation of ES cells with pancreatic rudiments induced a significant increase in the proportion of lacZ positive cell numbers and this increase was further enhanced by forced expression of a chick putative endoderm inducer gene, cmix [2].
A mouse Mix-like gene, Mml, related to the Xenopus Mix/Bix homeobox gene family and the chick CMIX gene has been identified [3].
In the fully-extended streak, CMIX is restricted to its middle, i.e. the prospective ventral mesoderm [4].
CMIX, a paired-type homeobox gene expressed before and during formation of the avian primitive streak [4].

Anatomical context of CMIX

CMIX is expressed early in embryogenis in a sickle-shaped area in the posterior zone of the blastoderm [4].
1. CMIX is expressed in the epiblast of the posterior marginal zone of early chick embryos, and later along the entire anterior-posterior axis of the primitive streak in cells of the medial ectoderm, in nascent mesoderm, but not in endoderm [5].

References

Nuclear beta-catenin and the development of bilateral symmetry in normal and LiCl-exposed chick embryos. Roeser, T., Stein, S., Kessel, M. Development (1999) [Pubmed]
TGF-beta signaling potentiates differentiation of embryonic stem cells to Pdx-1 expressing endodermal cells. Shiraki, N., Lai, C.J., Hishikari, Y., Kume, S. Genes Cells (2005) [Pubmed]
Mml, a mouse Mix-like gene expressed in the primitive streak. Pearce, J.J., Evans, M.J. Mech. Dev. (1999) [Pubmed]
CMIX, a paired-type homeobox gene expressed before and during formation of the avian primitive streak. Stein, S., Roeser, T., Kessel, M. Mech. Dev. (1998) [Pubmed]
Characterization of CMIX, a chicken homeobox gene related to the Xenopus gene mix.1. Peale, F.V., Sugden, L., Bothwell, M. Mech. Dev. (1998) [Pubmed]

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