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Gene Review

Mixl1  -  Mix1 homeobox-like 1 (Xenopus laevis)

Mus musculus

Synonyms: Homeobox protein MIXL1, Homeodomain protein MIX, MIX1 homeobox-like protein 1, Mix, Mix.1 homeobox-like protein, ...
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Disease relevance of Mixl1

  • The effect of recombinant human interleukin-6 (rhIL-6) on induction of nitrite (NO(-2)) production was investigated in a mouse myeloid leukemia cell line (M1) and a subclone (Mm1) [1].
  • Antibody-mediated enhancement of dengue virus infection in mouse macrophage cell lines, Mk1 and Mm1 [2].
  • Mml loci have been identified as provirus integration sites among a subset of monocytic tumours induced by murine leukaemia virus (MuLV) infection of BALB/c and DBA/2 mice [3].

High impact information on Mixl1


Biological context of Mixl1


Anatomical context of Mixl1


Associations of Mixl1 with chemical compounds


Other interactions of Mixl1

  • Mixl1-null ES cells, however, displayed a haematopoietic defect characterised by reduced and delayed Flk1 expression and a decrease in the frequency of haematopoietic CFCs [7].

Analytical, diagnostic and therapeutic context of Mixl1

  • No requirement of divalent cation (Mg++, Ca++) and metabolic energy was observed for rosette formation between Mm1 cells and QRC [8].
  • The flow cytometry pattern in IL-6-treated Mm1 was the same as that of cytochalasin B-treated Mm1 [12].
  • The sensitivity of the target cells differed in co-cultures of antigen-primed splenocytes and B cell hybridomas with IL-6-treated Mm1 [10].


  1. Effect of recombinant human interleukin-6 on nitrite production of mouse myeloid leukemia cells. Takagi, K., Hosaka, T., Suketa, Y. J. Cell. Physiol. (1991) [Pubmed]
  2. Antibody-mediated enhancement of dengue virus infection in mouse macrophage cell lines, Mk1 and Mm1. Hotta, H., Wiharta, A.S., Hotta, S. Proc. Soc. Exp. Biol. Med. (1984) [Pubmed]
  3. Linkage on chromosome 10 of several murine retroviral integration loci associated with leukaemia. Haviernik, P., Festin, S.M., Opavsky, R., Koller, R.P., Barr, N.I., Neil, J.C., Wolff, L. J. Gen. Virol. (2002) [Pubmed]
  4. Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia. Glaser, S., Metcalf, D., Wu, L., Hart, A.H., Dirago, L., Mifsud, S., D'Amico, A., Dagger, S., Campo, C., Chan, A.C., Izon, D.J., Robb, L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation. Tam, P.P., Khoo, P.L., Lewis, S.L., Bildsoe, H., Wong, N., Tsang, T.E., Gad, J.M., Robb, L. Development (2007) [Pubmed]
  6. Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Hart, A.H., Hartley, L., Sourris, K., Stadler, E.S., Li, R., Stanley, E.G., Tam, P.P., Elefanty, A.G., Robb, L. Development (2002) [Pubmed]
  7. The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells. Ng, E.S., Azzola, L., Sourris, K., Robb, L., Stanley, E.G., Elefanty, A.G. Development (2005) [Pubmed]
  8. A lectinlike receptor on murine macrophage cell line cells, Mm1: involvement of sialic acid-binding sites in opsonin-independent phagocytosis for xenogeneic red cells. Kyoizumi, S., Masuda, T. J. Leukoc. Biol. (1985) [Pubmed]
  9. Molecular characterisation of ninein, a new coiled-coil protein of the centrosome. Bouckson-Castaing, V., Moudjou, M., Ferguson, D.J., Mucklow, S., Belkaid, Y., Milon, G., Crocker, P.R. J. Cell. Sci. (1996) [Pubmed]
  10. Inhibitory mechanisms of antibody production by nitrogen oxides released from activated macrophages during the immune response: relationship to energy consumption. Takagi, K., Nukaya, I., Yasukawa, K., Suketa, Y. Immunol. Cell Biol. (1994) [Pubmed]
  11. Differentiation-associated changes of glycolipid composition and metabolism in mouse myeloid leukemia cells. Induction of globotriaosylceramide and a galactosyltransferase. Taki, T., Kawamoto, M., Seto, H., Noro, N., Masuda, T., Kannagi, R., Matsumoto, M. J. Biochem. (1983) [Pubmed]
  12. Nitric oxide blocks the cell cycle of mouse macrophage-like cells in the early G2+M phase. Takagi, K., Isobe, Y., Yasukawa, K., Okouchi, E., Suketa, Y. FEBS Lett. (1994) [Pubmed]
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