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Gene Review

NODAL  -  nodal growth differentiation factor

Gallus gallus

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High impact information on NODAL

  • We also show that FGF signalling is required for primitive streak formation, in cooperation with Nodal and Chordin [1].
  • We show that Nr1, a chick nodal homologue, is expressed in the nascent prechordal mesoderm and we provide evidence that Nodal signalling can cooperate with Shh to induce the epiblast precursors to a floor-plate fate [2].
  • BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo [3].
  • We propose a novel model of left-right axis formation, which involves BMP as a positive regulator of Nodal signaling in the chick embryo [3].
  • We implanted BMP2 and Noggin-expressing cells into the left lateral plate and paraxial mesoderm and observed a strong upregulation of Nodal and its target genes Pitx2 and Nkx3 [3].

Biological context of NODAL

  • Treatment of cultured chick embryos with lindane, which diminishes gap junctional communication, frequently unbiased normal LR asymmetry of Shh and Nodal gene expression, causing the normally left-sided program to be recapitulated symmetrically on the right side of the embryo [4].

Anatomical context of NODAL


Regulatory relationships of NODAL

  • A model of left-right axis formation in the chick involves inhibition of bone morphogenetic proteins by the antagonist Car as a mechanism of upregulating Nodal in the left lateral plate mesoderm [3].

Other interactions of NODAL

  • Both the adhesion protein N-cadherin and PKI (an endogenous protein kinase A inhibitor) are localized to the right side of the node and may contribute to restrict Nodal activation by Wnt signaling and PKA to the left side of the node [5].


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