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Gene Review

SOD1  -  superoxide dismutase 1, soluble

Gallus gallus

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Disease relevance of SOD1


High impact information on SOD1


Biological context of SOD1

  • These results suggest that MTSOD1 and truncated WTSOD1 lead to neural cell death because of misfolding, and that SOD1 peptides, possibly as a result of proteolytic digestion of MTSOD, play a role in FALS pathogenesis [1].


  1. Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord. Ghadge, G.D., Wang, L., Sharma, K., Monti, A.L., Bindokas, V., Stevens, F.J., Roos, R.P. Neurobiol. Dis. (2006) [Pubmed]
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