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Gene Review

GLI2  -  GLI family zinc finger 2

Gallus gallus

Synonyms: GLI2/GLI4, GLI3
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Disease relevance of GLI2


High impact information on GLI2

  • Our analysis of expression of putative components of the Shh pathway, gli1, gli3 and coupTFII shows that genes regulated by Shh are either ectopically expressed or no longer responsive to Shh signals in talpid3 limbs, suggesting possible bifurcation in the Shh pathway [2].
  • Similar expression and regulation of Gli2 and Gli3 in the chick limb bud [3].


  1. Analysis of glia cell differentiation in the developing chick peripheral nervous system: sensory and sympathetic satellite cells express different cell surface antigens. Rüdel, C., Rohrer, H. Development (1992) [Pubmed]
  2. Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway. Lewis, K.E., Drossopoulou, G., Paton, I.R., Morrice, D.R., Robertson, K.E., Burt, D.W., Ingham, P.W., Tickle, C. Development (1999) [Pubmed]
  3. Similar expression and regulation of Gli2 and Gli3 in the chick limb bud. Schweitzer, R., Vogan, K.J., Tabin, C.J. Mech. Dev. (2000) [Pubmed]
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