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Gene Review

gli2a  -  GLI family zinc finger 2a

Danio rerio

Synonyms: SO:0000704, fc85b05, gli2, wu:fc85b05, yot


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High impact information on gli2a


Biological context of gli2a

  • Indeed, morpholino-mediated knockdown of Gli2(DR) protein in yot mutants led to a suppression of the defective motor neuron phenotype [3].
  • Two yot mutant alleles with midline lenses likely encode dominant negative forms of the Gli2 protein which will interfere with transcriptional activation by other Gli proteins [4].
  • We report here the characterization of a zebrafish Gli2 expression in slow and fast muscle cells and the study of the roles of Hedgehogs and Gli2 in zebrafish muscle development using two mutant strains; sonic-you (syu) and you-too (yot), respective for sonic hedgehog (shh) and Gli2 mutation [5].

Anatomical context of gli2a

  • Motor neuron induction at all axial levels was reduced in yot (gli2(DR)) mutant embryos [3].
  • In flh, syu, and yot mutants, glomeruli differentiate at ectopic lateral positions within the embryo and contain morphologically identifiable podocyte and endothelial cell types [6].
  • We show here that the zebrafish midline mutants you-too (yot) and iguana (igu) develop lenses from the adenohypophysis anlage [4].
  • In yot mutant embryos, development of slow muscles was completely blocked, whereas in syu mutant embryos, a small number of slow muscle cells could still form, suggesting that other Hhs were also involved in slow muscle induction [5].
  • We show that the absence of myotomal adaxial cells in you-too/gli2 embryos severely impairs secondary motor axonal pathfinding, including their ability to project into the somites [7].

Regulatory relationships of gli2a

  • Induction of slow muscles by other Hhs appeared to require Gli2, because ectopic expression of Echidna hedgehog (Ehh) and Tiggy-winkle hedgehog (Twhh) failed to induce slow muscles in yot mutant embryos [5].
  • Minhas et al. 2015 have elucidated a subset of cis-regulatory elements controlling GLI2 expression. They have shown that conserved non-coding elements (CNEs) from the intron of GLI2 gene act as tissue-specific enhancers and reporter gene expression induced by these elements correlates with previously reported endogenous gli2 expression in zebrafish. The regulatory activities of these elements are observed in several embryonic domains, including neural tube and pectoral fin [Ref].

Other interactions of gli2a


  1. Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning. Karlstrom, R.O., Talbot, W.S., Schier, A.F. Genes Dev. (1999) [Pubmed]
  2. Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Karlstrom, R.O., Tyurina, O.V., Kawakami, A., Nishioka, N., Talbot, W.S., Sasaki, H., Schier, A.F. Development (2003) [Pubmed]
  3. Gli function is essential for motor neuron induction in zebrafish. Vanderlaan, G., Tyurina, O.V., Karlstrom, R.O., Chandrasekhar, A. Dev. Biol. (2005) [Pubmed]
  4. Zebrafish mutations in Gli-mediated hedgehog signaling lead to lens transdifferentiation from the adenohypophysis anlage. Kondoh, H., Uchikawa, M., Yoda, H., Takeda, H., Furutani-Seiki, M., Karlstrom, R.O. Mech. Dev. (2000) [Pubmed]
  5. Gli2 mediation of hedgehog signals in slow muscle induction in zebrafish. Du, S.J., Dienhart, M. Differentiation (2001) [Pubmed]
  6. The zebrafish floating head mutant demonstrates podocytes play an important role in directing glomerular differentiation. Majumdar, A., Drummond, I.A. Dev. Biol. (2000) [Pubmed]
  7. Migration of zebrafish spinal motor nerves into the periphery requires multiple myotome-derived cues. Zeller, J., Schneider, V., Malayaman, S., Higashijima, S., Okamoto, H., Gui, J., Lin, S., Granato, M. Dev. Biol. (2002) [Pubmed]
  8. Zebrafish wnt4b expression in the floor plate is altered in sonic hedgehog and gli-2 mutants. Liu, A., Majumdar, A., Schauerte, H.E., Haffter, P., Drummond, I.A. Mech. Dev. (2000) [Pubmed]
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