Gene Review:
GLI2 - GLI family zinc finger 2
Homo sapiens
Synonyms:
CJS, GLI family zinc finger protein 2, HPE9, PHS2, THP, ...
- Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma. Regl, G., Neill, G.W., Eichberger, T., Kasper, M., Ikram, M.S., Koller, J., Hintner, H., Quinn, A.G., Frischauf, A.M., Aberger, F. Oncogene (2002)
- Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Regl, G., Kasper, M., Schnidar, H., Eichberger, T., Neill, G.W., Philpott, M.P., Esterbauer, H., Hauser-Kronberger, C., Frischauf, A.M., Aberger, F. Cancer Res. (2004)
- Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase. Bhatia, N., Thiyagarajan, S., Elcheva, I., Saleem, M., Dlugosz, A., Mukhtar, H., Spiegelman, V.S. J. Biol. Chem. (2006)
- Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer. Mukherjee, S., Frolova, N., Sadlonova, A., Novak, Z., Steg, A., Page, G.P., Welch, D.R., Lobo-Ruppert, S.M., Ruppert, J.M., Johnson, M.R., Frost, A.R. Cancer Biol. Ther. (2006)
- Hemizygosity for chromosome 2q14.2-q22.1 spanning the GLI2 and PROC genes associated with growth hormone deficiency, polydactyly, deep vein thrombosis and urogenital abnormalities. Gustavsson, P., Schoumans, J., Staaf, J., Jönsson, G., Carlsson, F., Kristoffersson, U., Borg, A., Nordenskjöld, M., Dahl, N. Clin. Genet. (2006)
- GLI2 knockdown using an antisense oligonucleotide induces apoptosis and chemosensitizes cells to paclitaxel in androgen-independent prostate cancer. Narita, S., So, A., Ettinger, S., Hayashi, N., Muramaki, M., Fazli, L., Kim, Y., Gleave, M.E. Clin. Cancer Res. (2008)
- Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. El Andaloussi, A., Graves, S., Meng, F., Mandal, M., Mashayekhi, M., Aifantis, I. Nat. Immunol. (2006)
- Reversal of neurosteroid effects at alpha4beta2delta GABA(A) receptors triggers anxiety at puberty. Shen, H., Gong, Q.H., Aoki, C., Yuan, M., Ruderman, Y., Dattilo, M., Williams, K., Smith, S.S. Nat. Neurosci. (2007)
- Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Riobó, N.A., Lu, K., Ai, X., Haines, G.M., Emerson, C.P. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Concurrent chemoradiotherapy with cyclophosphamide, pirarubicin, and cisplatin for patients with locally advanced salivary gland carcinoma. Katori, H., Tsukuda, M. Acta Otolaryngol. (2006)
- The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells. Regl, G., Kasper, M., Schnidar, H., Eichberger, T., Neill, G.W., Ikram, M.S., Quinn, A.G., Philpott, M.P., Frischauf, A.M., Aberger, F. Oncogene (2004)
- GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. Ikram, M.S., Neill, G.W., Regl, G., Eichberger, T., Frischauf, A.M., Aberger, F., Quinn, A., Philpott, M. J. Invest. Dermatol. (2004)
- Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features. Roessler, E., Du, Y.Z., Mullor, J.L., Casas, E., Allen, W.P., Gillessen-Kaesbach, G., Roeder, E.R., Ming, J.E., Ruiz i Altaba, A., Muenke, M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- GLI2 mutations in four Brazilian patients: How wide is the phenotypic spectrum? Rahimov, F., Ribeiro, L.A., de Miranda, E., Richieri-Costa, A., Murray, J.C. Am. J. Med. Genet. A (2006)
- Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Hatsell, S.J., Cowin, P. Development (2006)
- Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human T-cell leukemia virus type 1 is responsible for transcriptional activation by tax protein. Dan, S., Tanimura, A., Yoshida, M. J. Virol. (1999)
- Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels. Kise, Y., Takenaka, K., Tezuka, T., Yamamoto, T., Miki, H. Biochem. Biophys. Res. Commun. (2006)
- Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. Haycraft, C.J., Banizs, B., Aydin-Son, Y., Zhang, Q., Michaud, E.J., Yoder, B.K. PLoS Genet. (2005)
- Vitamin E attenuates crystal formation in rat kidneys: roles of renal tubular cell death and crystallization inhibitors. Huang, H.S., Chen, J., Chen, C.F., Ma, M.C. Kidney Int. (2006)
- GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Hu, M.C., Mo, R., Bhella, S., Wilson, C.W., Chuang, P.T., Hui, C.C., Rosenblum, N.D. Development (2006)
- FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma. Eichberger, T., Regl, G., Ikram, M.S., Neill, G.W., Philpott, M.P., Aberger, F., Frischauf, A.M. J. Invest. Dermatol. (2004)
- Asymmetric expression of Gli transcription factors in Hensen's node. Granata, A., Quaderi, N.A. Gene Expr. Patterns (2005)
- The FU gene and its possible protein isoforms. Østerlund, T., Everman, D.B., Betz, R.C., Mosca, M., Nöthen, M.M., Schwartz, C.E., Zaphiropoulos, P.G., Toftgård, R. BMC Genomics (2004)
- Importance of carbohydrate in the interaction of Tamm-Horsfall protein with complement 1q and inhibition of classical complement activation. Rhodes, D.C. Immunol. Cell Biol. (2006)
- Determination of DL-tetrahydropalmatine in Corydalis yanhusuo by L-tetrahydropalmatine imprinted monolithic column coupling with reversed-phase high performance liquid chromatography. Ou, J., Kong, L., Pan, C., Su, X., Lei, X., Zou, H. Journal of chromatography. A. (2006)
- Genetic analysis of anal atresia in pigs: evidence for segregation at two main loci. Cassini, P., Montironi, A., Botti, S., Hori, T., Okhawa, H., Stella, A., Andersson, L., Giuffra, E. Mamm. Genome (2005)
- Immunological detection of nitrosative stress-mediated modified Tamm-Horsfall glycoprotein (THP) in calcium oxalate stone formers. Pragasam, V., Kalaiselvi, P., Sumitra, K., Srinivasan, S., Anandkumar, P., Varalakshmi, P. Biomarkers (2006)
- Tamm-Horsfall protein in recurrent calcium kidney stone formers with positive family history: abnormalities in urinary excretion, molecular structure and function. Jaggi, M., Nakagawa, Y., Zipperle, L., Hess, B. Urol. Res. (2007)