High impact information on SI

• Guinea pig serum raised to purified rabbit SI complex inhibited bacterial adherence to microvilli [1].
• The activity of jejunal sucrase-isomaltase (SI) was higher (P < 0.05) 48 h after IO feeding in all the IO fed embryos, whereas at day of hatch and at d 3 the CHO+HMB IO group had the highest maltase activity (P < 0.05), which was approximately 50% greater than control embryos [2].
• CdxA protein was shown to bind to the promoter region of SI in the chick indicating that cdxA is similar to the mammalian cdx2 [3].
• 6. The addition of HMC to the diet markedly affected the morphology of the intestinal wall and significantly increased the number of goblet cells per 100 villus cells and the sucrase isomaltase activity was increased significantly [4].
• The intestinal sucrase-isomaltase (SI) complex is a glycoprotein of the small intestine brush border membrane that plays an important role in the final degradation of carbohydrate [5].

Associations of SI with chemical compounds

• 2) The molecular weights of sucrase-isomaltase complex, maltase I, maltase II, maltase III and isomaltase dissociated from sucrase-isomaltase complex were estimated to be 250,000, 250,000, 160,000, 225,000 and 80,000, respectively, by polyacrylamide disc gel electrophoresis [6].

Analytical, diagnostic and therapeutic context of SI

• To clone the chicken SI, we employed reverse transcriptase polymerase chain reaction (RT-PCR) [5].
• Both preparations contain a high-molecular weight polypeptide of approximately 250 kDa which in the case of sucrase-isomaltase could be identified by peptide mapping as a single-chain precursor not (yet) proteolytically processed to the final heterodimer [7].

References