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EFNA5  -  ephrin-A5

Gallus gallus

 
 
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High impact information on EFNA5

  • However, when added in soluble form to the medium, ephrin-A5 induces growth cone collapse, comparable to data from chick [1].
  • Graded expression of the Eph receptor EphA3 in the retina and its two ligands, ephrin A2 and ephrin A5 in the optic tectum, the primary target of retinal axons, have been implicated in the formation of the retinotectal projection map [2].
  • Spatiotemporal expression patterns of six members of the Eph gene family (EphA4, EphA3, EphB2, ephrin-B1, ephrin-A2, and ephrin-A5) were characterized immunocytochemically at various stages of chick cerebellar development [3].
  • Ephrin-A5 inhibits growth of embryonic sensory neurons [4].
  • We demonstrate that in vivo overexpression of ephrin-A5 in the intermandibularis muscle, or overexpression of dominant-negative EphA receptors in trigeminal motor neurons leads to a reduction in branching of r3-derived motor axons specifically [5].
 

Anatomical context of EFNA5

  • On average, growth cones that collapsed in response to soluble ephrin-A5 extended more slowly than those that did not, and ephrin-A5 significantly slowed the extension of NGF-dependent growth cones that did not collapse [4].
  • Here, we show that distinct subsets of motor neurons that express EphA4 respond differently to ephrin-A5 [6].
  • Blocking EphA4 activation in MMC(m) neurons or expanding the domain of ephrin-A5 expression in the somite results in the aberrant growth of MMC(m) axons into the caudal half-sclerotome [6].
  • EphA4-positive LMC(l) axons avoid entering ephrin-A5-positive hindlimb mesoderm [6].
  • Here, we show that the expression of the Eph receptors -A4 and -A7, and of their ligands ephrin-A5 and -A2 correlates with the establishment of territories along the rostro-caudal axis and with the formation of topographically organized connections between the cortex and the cerebellar nuclei [7].
 

Associations of EFNA5 with chemical compounds

  • This has been highlighted by studies demonstrating the role of opposing gradients of the EphA3 receptor tyrosine kinase on retinal axons and two of its ligands, ephrin-A2 and ephrin-A5, in the tectum [8].

References

  1. On the turning of Xenopus retinal axons induced by ephrin-A5. Weinl, C., Drescher, U., Lang, S., Bonhoeffer, F., Löschinger, J. Development (2003) [Pubmed]
  2. Two homeobox genes define the domain of EphA3 expression in the developing chick retina. Schulte, D., Cepko, C.L. Development (2000) [Pubmed]
  3. Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration. Karam, S.D., Burrows, R.C., Logan, C., Koblar, S., Pasquale, E.B., Bothwell, M. J. Neurosci. (2000) [Pubmed]
  4. Ephrin-A5 inhibits growth of embryonic sensory neurons. Muñoz, L.M., Zayachkivsky, A., Kunz, R.B., Hunt, J.M., Wang, G., Scott, S.A. Dev. Biol. (2005) [Pubmed]
  5. Ephrin-As play a rhombomere-specific role in trigeminal motor axon projections in the chick embryo. Prin, F., Ng, K.E., Thaker, U., Drescher, U., Guthrie, S. Dev. Biol. (2005) [Pubmed]
  6. Ephrin-A5 exerts positive or inhibitory effects on distinct subsets of EphA4-positive motor neurons. Eberhart, J., Barr, J., O'Connell, S., Flagg, A., Swartz, M.E., Cramer, K.S., Tosney, K.W., Pasquale, E.B., Krull, C.E. J. Neurosci. (2004) [Pubmed]
  7. Expression of EphA receptors and ligands during chick cerebellar development. Blanco, M.J., Peña-Melián, A., Nieto, M.A. Mech. Dev. (2002) [Pubmed]
  8. Differential expression of Eph receptors and ephrins correlates with the formation of topographic projections in primary and secondary visual circuits of the embryonic chick forebrain. Marín, O., Blanco, M.J., Nieto, M.A. Dev. Biol. (2001) [Pubmed]
 
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