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Gene Review

Efna5  -  ephrin A5

Mus musculus

Synonyms: AL-1, AV158822, EFL-5, EPH-related receptor tyrosine kinase ligand 7, Ephrin-A5, ...
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Disease relevance of Efna5


High impact information on Efna5

  • This is caused by the failure of the neural folds to fuse in the dorsal midline, suggesting that ephrin-A5, in addition to its involvement in cell repulsion, can participate in cell adhesion [2].
  • Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping [4].
  • These findings show that ephrin-A5 is required for the proper guidance and mapping of retinal axons in the mammalian midbrain [5].
  • This defect is consistent with the high level of ephrin-A5 expression in the IC and the finding that retinal axon growth on membranes from wild-type IC is inhibited relative to that on membranes from ephrin-A5-/- IC [5].
  • We have recently shown that ephrin-A5 signals within caveola-like domains of the plasma membrane upon engagement with its cognate Eph receptor, leading to increased adhesion of the cells to fibronectin [6].

Chemical compound and disease context of Efna5


Biological context of Efna5


Anatomical context of Efna5

  • In addition, ephrin-A1 and ephrin-A5 were seen in the forming blood vessels and alveolar bone, respectively [1].
  • Prior to birth, ephrin-A1, ephrin-A5, EphA2, and EphA4 transcripts were present in the cuspal area of the dental papilla including the preodontoblasts [1].
  • Here, we show complementary expression and binding for the receptor EphA5 in mouse retina and its ligands ephrin-A2 and ephrin-A5 in multiple retinal targets, including the major forebrain target, the dorsal lateral geniculate nucleus (dLGN) [13].
  • This hypothesis was supported by our demonstration that EphA3 can direct retinal ganglion cell axon targeting and by studies of ephrin-A5(-/-) mutants that show that EphA receptor signaling controls the topographic innervation of the acromiotrapezius [14].
  • In wild-type mice ephrin-A5 is expressed in a gradient in the somatosensory cortex during development [15].

Associations of Efna5 with chemical compounds


Other interactions of Efna5

  • Video microscopic analyses show that AC1(brl/brl) axons have modified responses to ephrin-A5: the collapse of the growth cones occurs, but the rearward movement of the axon is arrested [16].

Analytical, diagnostic and therapeutic context of Efna5


  1. Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues. Luukko, K., Løes, S., Kvinnsland, I.H., Kettunen, P. Cell Tissue Res. (2005) [Pubmed]
  2. Regulation of repulsion versus adhesion by different splice forms of an Eph receptor. Holmberg, J., Clarke, D.L., Frisén, J. Nature (2000) [Pubmed]
  3. Biological evaluation of some selected cyclic imides: mitochondrial effects and in vitro cytotoxicity. Prado, S.R., Cechinel-Filho, V., Campos-Buzzi, F., Corrêa, R., Cadena, S.M., de Oliveira, M.B. Z. Naturforsch., C, J. Biosci. (2004) [Pubmed]
  4. Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Feldheim, D.A., Kim, Y.I., Bergemann, A.D., Frisén, J., Barbacid, M., Flanagan, J.G. Neuron (2000) [Pubmed]
  5. Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Frisén, J., Yates, P.A., McLaughlin, T., Friedman, G.C., O'Leary, D.D., Barbacid, M. Neuron (1998) [Pubmed]
  6. Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner. Davy, A., Robbins, S.M. EMBO J. (2000) [Pubmed]
  7. Differential expression of two cell adhesion molecules, Ephrin-A5 and Integrin alpha6, during cranial neurulation in the chick embryo. Colas, J.F., Schoenwolf, G.C. Dev. Neurosci. (2003) [Pubmed]
  8. Expression domains of murine ephrin-A5 in the pituitary and hypothalamus. Zarbalis, K., Wurst, W. Mech. Dev. (2000) [Pubmed]
  9. The gene encoding LERK-7 (EPLG7, Epl7), a ligand for the Eph-related receptor tyrosine kinases, maps to human chromosome 5 at band q21 and to mouse chromosome 17. Cerretti, D.P., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Kuefer, M.U., Valentine, V., Shapiro, D.N., Cui, X., Morris, S.W. Genomics (1996) [Pubmed]
  10. Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Depaepe, V., Suarez-Gonzalez, N., Dufour, A., Passante, L., Gorski, J.A., Jones, K.R., Ledent, C., Vanderhaeghen, P. Nature (2005) [Pubmed]
  11. Miswiring of limbic thalamocortical projections in the absence of ephrin-A5. Uziel, D., Mühlfriedel, S., Zarbalis, K., Wurst, W., Levitt, P., Bolz, J. J. Neurosci. (2002) [Pubmed]
  12. Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5. Yue, Y., Su, J., Cerretti, D.P., Fox, G.M., Jing, S., Zhou, R. J. Neurosci. (1999) [Pubmed]
  13. Topographic guidance labels in a sensory projection to the forebrain. Feldheim, D.A., Vanderhaeghen, P., Hansen, M.J., Frisén, J., Lu, Q., Barbacid, M., Flanagan, J.G. Neuron (1998) [Pubmed]
  14. EphA3 null mutants do not demonstrate motor axon guidance defects. Vaidya, A., Pniak, A., Lemke, G., Brown, A. Mol. Cell. Biol. (2003) [Pubmed]
  15. Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knock-out mice revealed by in vivo functional imaging. Prakash, N., Vanderhaeghen, P., Cohen-Cory, S., Frisén, J., Flanagan, J.G., Frostig, R.D. J. Neurosci. (2000) [Pubmed]
  16. Requirement of adenylate cyclase 1 for the ephrin-A5-dependent retraction of exuberant retinal axons. Nicol, X., Muzerelle, A., Rio, J.P., Métin, C., Gaspar, P. J. Neurosci. (2006) [Pubmed]
  17. Ephrin-as guide the formation of functional maps in the visual cortex. Cang, J., Kaneko, M., Yamada, J., Woods, G., Stryker, M.P., Feldheim, D.A. Neuron (2005) [Pubmed]
  18. Regulation of hippocampal synaptic plasticity by the tyrosine kinase receptor, REK7/EphA5, and its ligand, AL-1/Ephrin-A5. Gao, W.Q., Shinsky, N., Armanini, M.P., Moran, P., Zheng, J.L., Mendoza-Ramirez, J.L., Phillips, H.S., Winslow, J.W., Caras, I.W. Mol. Cell. Neurosci. (1998) [Pubmed]
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