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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NOV  -  nephroblastoma overexpressed

Gallus gallus

 
 
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High impact information on NOV

  • During chick embryo development, NOV expression is tightly regulated in cartilage, and a high expression of NOV has been associated with cartilage differentiation in Wilms' tumors [1].
  • We studied the involvement of NOV/CCN3, whose function is poorly understood, in chondrocyte differentiation [1].
  • Assignment of the chicken NOV gene (alias CCN3) to chromosome 2q34-->q36: Conserved and compared synteny between avian, mouse and human [2].
  • Chicken NOV gene expression in the forming notochord and floor plate was observed until HH 18 [3].
  • We investigated the NOV gene expression pattern in the chicken during early stage embryogenesis [3].

References

  1. New target genes for NOV/CCN3 in chondrocytes: TGF-beta2 and type X collagen. Lafont, J., Jacques, C., Le Dreau, G., Calhabeu, F., Thibout, H., Dubois, C., Berenbaum, F., Laurent, M., Martinerie, C. J. Bone Miner. Res. (2005) [Pubmed]
  2. Assignment of the chicken NOV gene (alias CCN3) to chromosome 2q34-->q36: Conserved and compared synteny between avian, mouse and human. Coullin, P., Li, C.L., Ziercher, L., Auffray, C., Bernheim, A., Zoorob, R., Perbal, B. Cytogenet. Genome Res. (2002) [Pubmed]
  3. The expression of chicken NOV, a member of the CCN gene family, in early stage development. Katsube, K., Chuai, M.L., Liu, Y.C., Kabasawa, Y., Takagi, M., Perbal, B., Sakamoto, K. Brain Res. Gene Expr. Patterns (2001) [Pubmed]
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