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BCL2  -  B-cell CLL/lymphoma 2

Gallus gallus

 
 
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High impact information on BCL2

  • Moreover, inhibitor studies confirmed the essential role of BCL-2 for FLI-1-transformed erythroblast survival [1].
  • Analysis of FLI-1 mutants showed a correlation between the ability of FLI-1 to transactivate BCL-2 promoter sequences and their ability to inhibit apoptosis in the absence of Epo [1].
  • Furthermore, direct prevention of cell death using a retroviral vector expressing Bcl2 led to an increase in Shh expression [2].
  • Since PTHrP up-regulates BCL2 levels and prevents growth plate chondrocyte maturation and apoptosis, BCL2 mRNA levels were examined in irradiated growth plate chondrocytes, and a dose-dependent decrease was found [3].
 

Biological context of BCL2

References

  1. Direct regulation of BCL-2 by FLI-1 is involved in the survival of FLI-1-transformed erythroblasts. Lesault, I., Quang, C.T., Frampton, J., Ghysdael, J. EMBO J. (2002) [Pubmed]
  2. Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development. Sanz-Ezquerro, J.J., Tickle, C. Development (2000) [Pubmed]
  3. The role of autocrine growth factors in radiation damage to the epiphyseal growth plate. Pateder, D.B., Eliseev, R.A., O'Keefe, R.J., Schwarz, E.M., Okunieff, P., Constine, L.S., Puzas, J.E., Rosier, R.N. Radiat. Res. (2001) [Pubmed]
  4. FLI-1 inhibits differentiation and induces proliferation of primary erythroblasts. Pereira, R., Quang, C.T., Lesault, I., Dolznig, H., Beug, H., Ghysdael, J. Oncogene (1999) [Pubmed]
 
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