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Gene Review

LHX1  -  LIM homeobox 1

Gallus gallus

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High impact information on LHX1

  • Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes [1].
  • These findings point to a flexible hydrophobic core in the LIM1 domain allowing residual relative mobility of the two zinc fingers, which might be important to optimize the LIM1 interface for interaction with its physiological target molecule(s) and to compensate enthalpically for the entropy loss upon binding [2].

Biological context of LHX1

  • The LIM1 domain consists of two zinc binding sites of the CCHC and the CCCC type, respectively, which both contain two orthogonally arranged antiparallel beta-sheets and which are packed together by a hydrophobic core composed of residues from the zinc finger loop regions [2].


  1. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Tsuchida, T., Ensini, M., Morton, S.B., Baldassare, M., Edlund, T., Jessell, T.M., Pfaff, S.L. Cell (1994) [Pubmed]
  2. Structure and intramodular dynamics of the amino-terminal LIM domain from quail cysteine- and glycine-rich protein CRP2. Kontaxis, G., Konrat, R., Kräutler, B., Weiskirchen, R., Bister, K. Biochemistry (1998) [Pubmed]
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