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Gene Review

lhx1a  -  LIM homeobox 1a

Danio rerio

Synonyms: Homeobox protein Lim-1, LHX1, LIM homeobox protein 1, LIM/homeobox protein Lhx1, SO:0000704, ...
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High impact information on lhx1a

  • Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish [1].
  • Lim6 was transiently expressed in a restricted region of the anterior neural plate at the bud stage, distinct from the expression of lim1 in the notochord and the pronephros and pronephric ducts [2].
  • In 24 hr embryos, lim6 and lim1 were expressed in the fore-, mid-, and hindbrain and the spinal cord, except that lim1 mRNA was limited to two small domains in the telencephalon, whereas lim6 mRNA was widely expressed in this region [2].
  • This study compares the spatial and temporal expression pattern of the closely related lim6 and lim1 genes during early embryogenesis [2].


  1. Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish. Toyama, R., O'Connell, M.L., Wright, C.V., Kuehn, M.R., Dawid, I.B. Development (1995) [Pubmed]
  2. lim6, a novel LIM homeobox gene in the zebrafish: comparison of its expression pattern with lim1. Toyama, R., Dawid, I.B. Dev. Dyn. (1997) [Pubmed]
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