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Gene Review

Lhx1  -  LIM homeobox 1

Rattus norvegicus

Synonyms: Homeobox protein Lim-1, LIM homeobox protein 1, LIM/homeobox protein Lhx1, Lim-1, Lim1, ...
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Disease relevance of Lhx1

  • Furthermore, we show that the addition of nerve growth factor (NGF) to cultures of primary dorsal root ganglion neurons leads to the induction of Isl-1, Rlim and Lim-3 mRNA expression [1].

High impact information on Lhx1

  • In this report, we have shown that three members of the LIM-homeodomain gene family - Isl-1, Rlim and Lim-3 are expressed in adult rat sensory neurons [1].
  • This suggests that Rlim is related to regulation of genes that are specific to some neurons such as Purkinje cells in the adult [2].
  • The expression of Rlim was found in discrete regions, such as the Purkinje cell layer of the cerebellum and several nuclei of the hypothalamus, midbrain and pons [2].

Analytical, diagnostic and therapeutic context of Lhx1

  • Rlim, a LIM class homeodomain gene, was isolated from rat brain, and localized in the adult brain by in situ hybridization histochemistry [2].


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