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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Lhx1  -  LIM homeobox 1

Rattus norvegicus

Synonyms: Homeobox protein Lim-1, LIM homeobox protein 1, LIM/homeobox protein Lhx1, Lim-1, Lim1, ...
 
 
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Disease relevance of Lhx1

  • Furthermore, we show that the addition of nerve growth factor (NGF) to cultures of primary dorsal root ganglion neurons leads to the induction of Isl-1, Rlim and Lim-3 mRNA expression [1].
 

High impact information on Lhx1

  • In this report, we have shown that three members of the LIM-homeodomain gene family - Isl-1, Rlim and Lim-3 are expressed in adult rat sensory neurons [1].
  • This suggests that Rlim is related to regulation of genes that are specific to some neurons such as Purkinje cells in the adult [2].
  • The expression of Rlim was found in discrete regions, such as the Purkinje cell layer of the cerebellum and several nuclei of the hypothalamus, midbrain and pons [2].
 

Analytical, diagnostic and therapeutic context of Lhx1

  • Rlim, a LIM class homeodomain gene, was isolated from rat brain, and localized in the adult brain by in situ hybridization histochemistry [2].

References

  1. Nerve growth factor induces the expression of the LIM homeodomain transcription factor Isl-1 with the kinetics of an immediate early gene in adult rat dorsal root ganglion. Jameson, H.L., Lillycrop, K.A. Neurosci. Lett. (2001) [Pubmed]
  2. Distribution of Rlim, an LIM homeodomain gene, in the rat brain. Furuyama, T., Inagaki, S., Iwahashi, Y., Takagi, H. Neurosci. Lett. (1994) [Pubmed]
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