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Gene Review

RYR2  -  ryanodine receptor 2 (cardiac)

Sus scrofa

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High impact information on RYR2


Regulatory relationships of RYR2

  • Furthermore, a mutant CaM deficient in Ca2+ binding at all four Ca2+ sites significantly activated the RYR2 and acted as a competitive inhibitor of RYR2 regulation by wild-type Ca2+CaM [2].


  1. Tissue distribution of ryanodine receptor isoforms and alleles determined by reverse transcription polymerase chain reaction. Ledbetter, M.W., Preiner, J.K., Louis, C.F., Mickelson, J.R. J. Biol. Chem. (1994) [Pubmed]
  2. Regulation of the RYR1 and RYR2 Ca2+ release channel isoforms by Ca2+-insensitive mutants of calmodulin. Fruen, B.R., Black, D.J., Bloomquist, R.A., Bardy, J.M., Johnson, J.D., Louis, C.F., Balog, E.M. Biochemistry (2003) [Pubmed]
  3. Construction of a porcine YAC library and mapping of the cardiac muscle ryanodine receptor gene to chromosome 14q22-q23. Leeb, T., Rettenberger, G., Hameister, H., Brem, G., Brenig, B. Mamm. Genome (1995) [Pubmed]
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