High impact information on TFRC

• IRE-BP is required in the posttranscriptional regulation of ferritin mRNA translation and stabilization of transferrin receptor mRNA [1].
• Using an antibody coated, magnetic core bead, it has been shown unequivocally that vesicles that contain the transferrin receptor also contain other plasma membrane activities, such as the nucleoside transporter and acetylcholinesterase [2].
• Reticulocyte maturation and exosome release: transferrin receptor containing exosomes shows multiple plasma membrane functions [2].
• Transferrin receptor kinetics showed that the transferrin receptor internalization rate in iron-enriched cultures was higher, whereas the transferrin receptor externalization rate in iron-enriched cultures was lower than the rate in iron-depleted cultures [3].
• 2. Since mucosal transferrin was found intimately entrapped on membranes, we hypothesize that a K88ab fimbriae-transferrin-cell transferrin receptor complex might allow the bacteria to adhere to specific sites of the mucosa [4].

Anatomical context of TFRC

• In an extensive series of experiments in primary cultures of porcine blood-brain barrier endothelial cells, we separately quantified surface-bound and total cellular transferrin receptor pools [5].
• Transferrin receptor mRNA expression in liver was induced as soon as iron levels decreased early in scurvy, which is similar to results reported for iron-depleted cultured cells [6].
• In vitro incubations of maternal bone marrow cells (MBMC) and fetal erythroid liver cells (FELC) with doubly labelled TfSlow and TfFast revealed only slight differences in affinities for the transferrin receptor [7].

References