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Gene Review

SREBF1  -  sterol regulatory element binding...

Sus scrofa

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High impact information on SREBP-1C

  • Our present experiments demonstrate that polyunsaturated FA regulate the gene expression of ADD1 and enzymes involved in lipid metabolism in porcine adipocytes [1].
  • Thus, although all three FAs decreased the ADD1 mRNA and protein concentrations, C20:4 and 9,11-CLA increased differentiation, measured by Oil Red O staining, whereas C22:6 did not [2].
  • The effects of arachidonic acid (C20:4), docosahexaenoic acid (C22:6), and cis 9, trans 11-conjugated linoleic acid (9,11-CLA) on differentiating preadipocyte ADD1 mRNA and protein and on preadipocyte differentiation were determined [2].
  • These results indicate that retinoic acid inhibits porcine preadipocyte differentiation by a mechanism that involves activation of the RAR and downregulation of PPARgamma, RXRalpha, and SREBP-1C mRNA [3].

Anatomical context of SREBP-1C

  • The ADD1 transcripts are expressed to a considerable extent in porcine adipocytes [2].


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