Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

SREBF1 - sterol regulatory element binding...

Sus scrofa

Synonyms: ADD1, SCREBP1, SREBP-1C, SREBP1

Ding, S.T. et al., Brandebourg, T.D. et al., Hsu, J.M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SREBP-1C

Our present experiments demonstrate that polyunsaturated FA regulate the gene expression of ADD1 and enzymes involved in lipid metabolism in porcine adipocytes [1].
Thus, although all three FAs decreased the ADD1 mRNA and protein concentrations, C20:4 and 9,11-CLA increased differentiation, measured by Oil Red O staining, whereas C22:6 did not [2].
The effects of arachidonic acid (C20:4), docosahexaenoic acid (C22:6), and cis 9, trans 11-conjugated linoleic acid (9,11-CLA) on differentiating preadipocyte ADD1 mRNA and protein and on preadipocyte differentiation were determined [2].
These results indicate that retinoic acid inhibits porcine preadipocyte differentiation by a mechanism that involves activation of the RAR and downregulation of PPARgamma, RXRalpha, and SREBP-1C mRNA [3].

Anatomical context of SREBP-1C

The ADD1 transcripts are expressed to a considerable extent in porcine adipocytes [2].

References

Effect of polyunsaturated fatty acids on the expression of transcription factor adipocyte determination and differentiation-dependent factor 1 and of lipogenic and fatty acid oxidation enzymes in porcine differentiating adipocytes. Hsu, J.M., Ding, S.T. Br. J. Nutr. (2003) [Pubmed]
Modulation of adipocyte determination and differentiation-dependent factor 1 by selected polyunsaturated fatty acids. Ding, S.T., McNeel, R.L., Mersmann, H.J. In Vitro Cell. Dev. Biol. Anim. (2002) [Pubmed]
Regulation of differentiating pig preadipocytes by retinoic acid. Brandebourg, T.D., Hu, C.Y. J. Anim. Sci. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.