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Gene Review

RXRA  -  retinoid X receptor, alpha

Sus scrofa

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High impact information on RXRA

  • RAR alpha gene expression increased (p < 0.05) in a linear fashion from 2- to 8-mm spherical conceptuses, and expression plateaued in the 9- to 12-mm conceptuses [1].
  • Hence, retinoic acid, a powerful morphogen, may serve a critical function in trophoblastic remodeling and conceptus elongation through the various isoforms of retinoic acid receptor (RAR) [1].
  • We hypothesize that various transcripts for RAR will be expressed, possibly differentially, in the early developing porcine conceptus on Days 10-12 of gestation [1].
  • These results indicate that retinoic acid inhibits porcine preadipocyte differentiation by a mechanism that involves activation of the RAR and downregulation of PPARgamma, RXRalpha, and SREBP-1C mRNA [2].
  • Weanling male Hartley guinea pigs were treated ip via osmotic pump for up to 14 days with vehicle or 0.50 to 5.5 mg/kg/day of the retinoic acid receptor (RAR)-selective agonist AGN 190121 [3].

Anatomical context of RXRA


  1. Detection of transcripts for retinoic acid receptors, retinol-binding protein, and transforming growth factors during rapid trophoblastic elongation in the porcine conceptus. Yelich, J.V., Pomp, D., Geisert, R.D. Biol. Reprod. (1997) [Pubmed]
  2. Regulation of differentiating pig preadipocytes by retinoic acid. Brandebourg, T.D., Hu, C.Y. J. Anim. Sci. (2005) [Pubmed]
  3. Retinoid-induced epiphyseal plate closure in guinea pigs. Standeven, A.M., Davies, P.J., Chandraratna, R.A., Mader, D.R., Johnson, A.T., Thomazy, V.A. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1996) [Pubmed]
  4. Porcine conceptus and endometrial retinoid-binding proteins. Harney, J.P., Ali, M., Vedeckis, W.V., Bazer, F.W. Reprod. Fertil. Dev. (1994) [Pubmed]
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