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Gene Review

HPRT1  -  hypoxanthine phosphoribosyltransferase 1

Sus scrofa

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High impact information on HPRT1


Biological context of HPRT1

  • All five of the hybrid clones which had retained the pig X-chromosome exhibited concordant expression of pig HPRT, G6PD, and alpha-GAL enzymes [4].

Associations of HPRT1 with chemical compounds

  • The ratio of HGPRTase with hypoxanthine as a substrate to APRTase activity in normal and hyperkeratotic epidermis was found to be 0.94 and 0.60, respectively [5].
  • The HGPRTase and APRTase activities expressed as micromoles per gram wet weight per min. were increased in experimental hyperkeratotic epidermis and it is suggested that the salvage pathway for purine nucleotide biosynthesis is activated in experimental hyperkeratotic epidermis [5].


  1. High frequency oscillatory ventilation suppresses inflammatory response in lung tissue and microdissected alveolar macrophages in surfactant depleted piglets. von der Hardt, K., Kandler, M.A., Fink, L., Schoof, E., Dötsch, J., Brandenstein, O., Bohle, R.M., Rascher, W. Pediatr. Res. (2004) [Pubmed]
  2. Laser-assisted microdissection and real-time PCR detect anti-inflammatory effect of perfluorocarbon. von der Hardt, K., Kandler, M.A., Fink, L., Schoof, E., Dotsch, J., Bohle, R.M., Rascher, W. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  3. The effect of nutritional state and allopurinol on nucleotide formation in enterocytes from the guinea pig small intestine. Gross, C.J., Savaiano, D.A. Biochim. Biophys. Acta (1991) [Pubmed]
  4. The localization of genes for HPRT, G6PD, and alpha-GAL onto the X-chromosome of domestic pig (Sus scrofa domesticus). Leong, M.M., Lin, C.C., Ruth, R.F. Can. J. Genet. Cytol. (1983) [Pubmed]
  5. Purine phosphoribosyltransferase activities in guinea pig epidermis. Matsuo, I., Ohkido, M., Kizaki, H., Sakurada, T. J. Dermatol. (1977) [Pubmed]
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