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Gene Review

ICAM-1  -  intercellular adhesion molecule-1

Sus scrofa

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Disease relevance of ICAM-1


High impact information on ICAM-1


Chemical compound and disease context of ICAM-1


Biological context of ICAM-1


Anatomical context of ICAM-1


Associations of ICAM-1 with chemical compounds


Other interactions of ICAM-1

  • In the absence of cytokine stimulation, chondrocyte-peripheral blood mononuclear cell (PBMC) interactions were unaffected by inhibition of ICAM-1-dependent pathways but were significantly reduced by blockade of CD18- and RGD-dependent pathways [11].
  • Additionally, the mRNA expression for IL-6R, ICAM-1, MCP-1, and TGF-beta was determined in each organ [19].
  • After laser-assisted microdissection of different lung cell types, mRNA expression of IL-8 and ICAM-1 was determined using TaqMan real-time PCR normalized to hypoxanthine phosphoribosyltransferase (HPRT) [20].
  • TGF-beta 1 causes increased endothelial ICAM-1 expression and lung injury [10].
  • In co-cultivation with the brain endothelial cell model, the malaria-activated PBMC stimulated the expression of E-selectin and ICAM-1 on the PBCEC [21].

Analytical, diagnostic and therapeutic context of ICAM-1


  1. Endothelial cell expression of the intercellular adhesion molecule-1 (ICAM-1) in the central nervous system of guinea pigs during acute and chronic relapsing experimental allergic encephalomyelitis. Wilcox, C.E., Ward, A.M., Evans, A., Baker, D., Rothlein, R., Turk, J.L. J. Neuroimmunol. (1990) [Pubmed]
  2. Effect of anti-ICAM-1 on bronchial response: bronchoalveolar lavage fluid (BALF) and ultrastructural changes of bronchial epithelium in guinea pigs with dual phase bronchial response. Tohda, Y., Kubo, H., Nakajima, S., Fukuoka, M. Methods and findings in experimental and clinical pharmacology. (1999) [Pubmed]
  3. Increased proteolytic activity and matrix metalloprotease expression in lungs during infection by porcine reproductive and respiratory syndrome virus. Girard, M., Cléroux, P., Tremblay, P., Dea, S., St-Pierre, Y. J. Gen. Virol. (2001) [Pubmed]
  4. Regulation of ICAM-1 and IL-6 in myocardial ischemia: effect of reperfusion. Kukielka, G.L., Youker, K.A., Hawkins, H.K., Perrard, J.L., Michael, L.H., Ballantyne, C.M., Smith, C.W., Entman, M.L. Ann. N. Y. Acad. Sci. (1994) [Pubmed]
  5. The relationship between the protective effect of amifostine and decreased intercellular adhesion molecule 1 expression. Wang, S.Z., Chen, Z.C., McNamar, J.P., Wang, S.Y., Cheng, Q.F. American journal of otolaryngology. (2005) [Pubmed]
  6. Lysophosphatidylcholine in oxidized low-density lipoprotein increases endothelial susceptibility to polymorphonuclear leukocyte-induced endothelial dysfunction in porcine coronary arteries. Role of protein kinase C. Sugiyama, S., Kugiyama, K., Ohgushi, M., Fujimoto, K., Yasue, H. Circ. Res. (1994) [Pubmed]
  7. Intravascular ultrasound molecular imaging of atheroma components in vivo. Hamilton, A.J., Huang, S.L., Warnick, D., Rabbat, M., Kane, B., Nagaraj, A., Klegerman, M., McPherson, D.D. J. Am. Coll. Cardiol. (2004) [Pubmed]
  8. Goblet cell degranulation after antigen challenge in sensitized guinea pigs. Role of neutrophils. Agusti, C., Takeyama, K., Cardell, L.O., Ueki, I., Lausier, J., Lou, Y.P., Nadel, J.A. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  9. Cloning of porcine intercellular adhesion molecule-1 and characterization of its induction on endothelial cells by cytokines. Stocker, C.J., Sugars, K.L., Yarwood, H., Delikouras, A., Lechler, R.I., Dorling, A., Landis, R.C., Morley, B.J., Haskard, D.O. Transplantation (2000) [Pubmed]
  10. TGF-beta 1 causes increased endothelial ICAM-1 expression and lung injury. Suzuki, Y., Tanigaki, T., Heimer, D., Wang, W., Ross, W.G., Murphy, G.A., Sakai, A., Sussman, H.H., Vu, T.H., Raffin, T.A. J. Appl. Physiol. (1994) [Pubmed]
  11. Chondrocyte-peripheral blood mononuclear cell interactions: the role of ICAM-1. Horner, A., Davies, M.E., Franz, B. Immunology (1995) [Pubmed]
  12. Gene expression in a swine model of right ventricular hypertrophy: intercellular adhesion molecule, vascular endothelial growth factor and plasminogen activators are upregulated during pressure overload. Carroll, S.M., Nimmo, L.E., Knoepfler, P.S., White, F.C., Bloor, C.M. J. Mol. Cell. Cardiol. (1995) [Pubmed]
  13. Reduction of monocyte adhesion to xenogenic tissue by endothelialization: an adhesion molecule and time-dependent mechanism. Gillis, C., Bengtsson, L., Haegerstrand, A. J. Thorac. Cardiovasc. Surg. (1995) [Pubmed]
  14. Correlation between ICAM-1 and functional recovery of piglet myocardium with leukocyte-depleted reperfusion. Lee, J.R., Han, J.J., Seo, J.W. Ann. Thorac. Surg. (2000) [Pubmed]
  15. Hog barn dust extract augments lymphocyte adhesion to human airway epithelial cells. Mathisen, T., Von Essen, S.G., Wyatt, T.A., Romberger, D.J. J. Appl. Physiol. (2004) [Pubmed]
  16. Increased neutrophil adherence to endothelial cells exposed to asbestos. Treadwell, M.D., Mossman, B.T., Barchowsky, A. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  17. Indoxyl sulfate stimulates renal synthesis of transforming growth factor-beta 1 and progression of renal failure. Miyazaki, T., Ise, M., Hirata, M., Endo, K., Ito, Y., Seo, H., Niwa, T. Kidney Int. Suppl. (1997) [Pubmed]
  18. Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. Huang, Q., Wu, M., Meininger, C., Kelly, K., Yuan, Y. Am. J. Physiol. (1998) [Pubmed]
  19. Organ-specific regulation of pro-inflammatory molecules in heart, lung, and kidney following brain death. Skrabal, C.A., Thompson, L.O., Potapov, E.V., Southard, R.E., Joyce, D.L., Youker, K.A., Noon, G.P., Loebe, M. J. Surg. Res. (2005) [Pubmed]
  20. Laser-assisted microdissection and real-time PCR detect anti-inflammatory effect of perfluorocarbon. von der Hardt, K., Kandler, M.A., Fink, L., Schoof, E., Dotsch, J., Bohle, R.M., Rascher, W. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  21. In vitro study of malaria parasite induced disruption of blood-brain barrier. Treeratanapiboon, L., Psathaki, K., Wegener, J., Looareesuwan, S., Galla, H.J., Udomsangpetch, R. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  22. Effect of long-term culture on the expression of antigens and adhesion molecule in single porcine pancreatic endocrine cells. Edamura, K., Nasu, K., Iwami, Y., Nishimura, R., Ogawa, H., Sasaki, N., Ohgawara, H. Xenotransplantation (2005) [Pubmed]
  23. Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors. Kopp, C.W., Siegel, J.B., Hancock, W.W., Anrather, J., Winkler, H., Geczy, C.L., Kaczmarek, E., Bach, F.H., Robson, S.C. Transplantation (1997) [Pubmed]
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