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Gene Review:

SPRP - small proline-rich protein

Sus scrofa

Chen, W.S. et al., Tesfaigzi, J. et al., Abraham, J.M. et al., Tesfaigzi, J. et al., Tesfaigzi, J. et al.

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Disease relevance of SPRP

A small proline-rich protein, SPRR1, is upregulated early during tobacco smoke-induced squamous metaplasia in rat nasal epithelia [1].

High impact information on SPRP

This is especially true for the expression of a small proline-rich protein (20K; 98 amino acids) in pig trachea epithelial cells [2].
Multigene families encode different small proline-rich proteins in different species, and these proteins are possible markers for squamous cell differentiation [2].
A small proline-rich protein regulated by vitamin A in tracheal epithelial cells is induced in lung tumors [3].
Change in morphology of cells was monitored under microscopy, and expression of beta-catenin, phosphorylated GSK3 and involucrin, a squamous differentiation marker, were dectected by Western blotting, while expression of mRNA of another squamous differentiation marker, small proline-rich protein, was detected by RT-PCR [4].

Biological context of SPRP

Esophagin constitutes the newest and largest member of this small proline-rich gene family and is associated with differentiation and the benign phenotype of the human esophageal epithelial cell [5].

Associations of SPRP with chemical compounds

The results demonstrated that lithium was able to induce a squamous morphology of the cells, and to enhance the expression of involucrin and small proline-rich protein mRNA [4].

References

A small proline-rich protein, SPRR1, is upregulated early during tobacco smoke-induced squamous metaplasia in rat nasal epithelia. Tesfaigzi, J., Th'ng, J., Hotchkiss, J.A., Harkema, J.R., Wright, P.S. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
Expression of the spr1 gene in cultured tracheal epithelial cells and its regulation by retinoids before and after confluence. Tesfaigzi, J., Carlson, D.M. J. Cell. Physiol. (1996) [Pubmed]
A small proline-rich protein regulated by vitamin A in tracheal epithelial cells is induced in lung tumors. Tesfaigzi, J., Wright, P.S., Oreffo, V., An, G., Wu, R., Carlson, D.M. Am. J. Respir. Cell Mol. Biol. (1993) [Pubmed]
Role of glycogen synthase kinase 3 in squamous differentiation of pig airway epithelial cells: A primary study. Chen, W.S., Wu, R.L., Tian, D., Wang, X. Sheng li xue bao [Acta physiologica Sinica]. (2005) [Pubmed]
Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors. Abraham, J.M., Wang, S., Suzuki, H., Jiang, H.Y., Rosenblum-Vos, L.S., Yin, J., Meltzer, S.J. Cell Growth Differ. (1996) [Pubmed]

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