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GNAI2  -  guanine nucleotide binding protein (G...

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Disease relevance of GNAI2

  • Reduced Gi alpha 2 content, in conjunction with increased Gs alpha content in the endocardium, may provide a means by which adrenergic activation is maintained in the setting of chronic episodic myocardial ischemia [1].
  • Activation of the Gi-2 protein by serotonergic or alpha 2-adrenoceptor stimulation decreased the pertussis toxin-catalyzed ADP-ribosylation of Gi alpha-2 protein in membranes from control but not lysoPC-treated cells [2].

High impact information on GNAI2


Analytical, diagnostic and therapeutic context of GNAI2

  • Quantitative immunoblotting showed that the cardiac inhibitory GTP-binding protein, Gi alpha 2, was decreased in the ischemic bed (P = 0.02) [1].


  1. Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia. Hammond, H.K., Roth, D.A., McKirnan, M.D., Ping, P. J. Clin. Invest. (1993) [Pubmed]
  2. Analysis of lysophophatidylcholine-induced endothelial dysfunction. Freeman, J.E., Kuo, W.Y., Drenger, B., Barnett, T.N., Levine, M.A., Flavahan, N.A. J. Cardiovasc. Pharmacol. (1996) [Pubmed]
  3. Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. Ping, P., Gelzer-Bell, R., Roth, D.A., Kiel, D., Insel, P.A., Hammond, H.K. J. Clin. Invest. (1995) [Pubmed]
  4. Gi proteins and the response to 5-hydroxytryptamine in porcine cultured endothelial cells with impaired release of EDRF. Day, N.S., Ge, T., Codina, J., Birnbaumer, L., Vanhoutte, P.M., Boulanger, C.M. Br. J. Pharmacol. (1995) [Pubmed]
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