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Gene Review

wnt4  -  wingless-type MMTV integration site family...

Xenopus laevis

Synonyms: Xwnt4, wnt-4, xwnt-4
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High impact information on Xwnt-4

  • Recombinant tissue and ectoderm alone were cultured until stage 14, when Xwnt-4 expression was assayed using Northern analysis [1].
  • The highest level of Xwnt-4 expression occurs during the early neurula stage of development although its expression persists throughout embryogenesis and can be found in the adult testis, brain and epithelium [1].
  • Xwnt-3, Xwnt-4, Xwnt-5A, and Xwnt-8 demonstrate between 35 and 50% amino acid identity with X. laevis Wnt-1/int-1 and most cysteine residues are conserved [2].
  • Xwnt-4 and Xwnt-3 transcripts are detected only during the neurula through tadpole stages of development [2].
  • The translational knockdown of XTRAP-gamma caused the suppression of tubulogenesis, the increase of Xlim-1 expression, and the decrease of Xpax-2 and Xwnt-4 expression [3].


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