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Gene Review

ventx1.1-a  -  VENT homeobox 1, gene 1

Xenopus laevis

Synonyms: Xvent-1b, pv.1, ventx1.1
 
 
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High impact information on PV.1

  • A novel homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos [1].
  • Here we report the identification of a novel Xenopus homeobox gene PV.1 (posterior-ventral 1) that is capable of mediating induction of ventral mesoderm [1].
  • Overexpression of PV.1 yields ventralized tadpoles and rescues embryos partially dorsalized by LiCl treatment [1].
  • PV.1 is expressed in the ventral marginal zone of blastulae and later in the posterior ventral area of gastrulae and neurulae [1].
  • Here we provide evidence that PV.1 also functions downstream of BMP4 in the patterning of ectoderm, specifying epidermal and suppressing neural gene expression [2].
 

Anatomical context of PV.1

  • The homeobox gene PV.1 mediates specification of the prospective neural ectoderm in Xenopus embryos [2].
  • We have previously shown that PV.1 is also preferentially expressed in the ventral endoderm, suggesting that this transcription factor may be involved in the ventralization of all three germ layers [2].
 

Other interactions of PV.1

 

Analytical, diagnostic and therapeutic context of PV.1

  • To address the physiological significance of these observations we employed an animal cap transplantation system and demonstrated that overexpression of PV.1 in the prospective neuroectoderm specifically blocks neurogenesis in intact embryos [2].

References

  1. A novel homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos. Ault, K.T., Dirksen, M.L., Jamrich, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. The homeobox gene PV.1 mediates specification of the prospective neural ectoderm in Xenopus embryos. Ault, K.T., Xu, R.H., Kung, H.F., Jamrich, M. Dev. Biol. (1997) [Pubmed]
  3. Active repression of organizer genes by C-terminal domain of PV.1. Hwang, Y.S., Lee, H.S., Roh, D.H., Cha, S., Lee, S.Y., Seo, J.J., Kim, J., Park, M.J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
 
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