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Gene Review

axin1  -  axin

Xenopus laevis

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High impact information on LOC398097


Biological context of LOC398097

  • Interestingly, the phenotype was rescued by ventral but not dorsal injection of axin mRNA, at the 4-cell stage, although dorsal injection into wild-type embryos does cause ventralization [5].

Anatomical context of LOC398097


Physical interactions of LOC398097

  • Regulation of the pathway occurs through a beta-catenin-degrading complex based on Axin and the tumor suppressor APC [7].
  • Although the connection between XAPC and the VCC dorsal factor is not yet clear, the fact that APC binds Axin suggests that the VCC dorsal factor could act on Axin rather than XGSK3 [8].

Other interactions of LOC398097

  • Finally, we show evidence that reexport is required for degradation of nuclear beta-catenin and that nuclei lack Axin, an essential component of the degradation machinery [7].
  • Secondly, we examined the effects of four Wnt-pathway-interfering constructs (dominant-negative Xdsh, XGSK3, Axin, and dominant-negative XTcf3) on the ability of VCC to induce expression of the early Wnt target genes, Siamois and Xnr3 [8].


  1. Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Salic, A., Lee, E., Mayer, L., Kirschner, M.W. Mol. Cell (2000) [Pubmed]
  2. The putative wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning. Sumanas, S., Strege, P., Heasman, J., Ekker, S.C. Development (2000) [Pubmed]
  3. A positive role for the PP2A catalytic subunit in Wnt signal transduction. Ratcliffe, M.J., Itoh, K., Sokol, S.Y. J. Biol. Chem. (2000) [Pubmed]
  4. Inhibition of Wnt signaling pathway by a novel axin-binding protein. Kadoya, T., Kishida, S., Fukui, A., Hinoi, T., Michiue, T., Asashima, M., Kikuchi, A. J. Biol. Chem. (2000) [Pubmed]
  5. The role of maternal axin in patterning the Xenopus embryo. Kofron, M., Klein, P., Zhang, F., Houston, D.W., Schaible, K., Wylie, C., Heasman, J. Dev. Biol. (2001) [Pubmed]
  6. Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain. Hedgepeth, C.M., Deardorff, M.A., Klein, P.S. Mech. Dev. (1999) [Pubmed]
  7. CRM1- and Ran-independent nuclear export of beta-catenin. Wiechens, N., Fagotto, F. Curr. Biol. (2001) [Pubmed]
  8. Relationship of vegetal cortical dorsal factors in the Xenopus egg with the Wnt/beta-catenin signaling pathway. Marikawa, Y., Elinson, R.P. Mech. Dev. (1999) [Pubmed]
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