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Gene Review:

mntH - manganese transport protein MntH

Escherichia coli UTI89

Patzer, S.I. et al., Huang, W. et al.

Patzer, Hantke,

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Disease relevance of mntH

Dual repression by Fe(2+)-Fur and Mn(2+)-MntR of the mntH gene, encoding an NRAMP-like Mn(2+) transporter in Escherichia coli [1].
To date, this specific pathway of regulating mntH expression has only been found in cyanobacteria [2].
This is a novel regulatory DNA motif in cyanobacteria, indicating that the expression of mntH was regulated by a two-component Mn(2+)-Sensing System containing ManR in Anabaena sp. PCC 7120 [2].

High impact information on mntH

In E. coli strains with chromosomal mntH-lacZ fusions, mntH was partially repressed by both Mn(2+) and Fe(2+) [1].
Binding of purified MntR to the mntH operator was manganese dependent [1].
The Fur binding site, localized within 22 nucleotides of the mntH operator by in vivo operator titration assays, resembles the Fur-box consensus sequence [1].
Electrophoretic mobility shift assays revealed that ManR specifically bound to the promoter region of the mntH gene [2].

References

Dual repression by Fe(2+)-Fur and Mn(2+)-MntR of the mntH gene, encoding an NRAMP-like Mn(2+) transporter in Escherichia coli. Patzer, S.I., Hantke, K. J. Bacteriol. (2001) [Pubmed]
The ManR specifically binds to the promoter of a Nramp transporter gene in Anabaena sp. PCC 7120: a novel regulatory DNA motif in cyanobacteria. Huang, W., Wu, Q. Biochem. Biophys. Res. Commun. (2004) [Pubmed]

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