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Gene Review

oxyR  -  DNA-binding transcriptional regulator OxyR

Escherichia coli UTI89

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Disease relevance of oxyR


High impact information on oxyR

  • To identify the region of OxyR that might contact RNA polymerase, we carried out alanine scanning and random mutagenesis of oxyR [3].
  • Overexpression of the oxyR gene in mammalian tumor cell lines protects them from hydrogen peroxide-induced cell death, and these cells are also highly resistant to the superoxide ion producing compound paraquat [1].

Biological context of oxyR

  • This transcriptional up-regulation was preserved in a strain with the DeltaoxyR::kan mutation, but it was abolished (ahpCF) or significantly reduced (oxyR and dps) in a strain with the rpoS::Tn10 mutation, potentially reflecting positive transcriptional regulation of the oxyR regulon by sigmaS [4].


  1. Oxy5, a novel protein from Arabidopsis thaliana, protects mammalian cells from oxidative stress. Kush, A., Sabapathy, K. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  2. OxyR regulated the expression of two major catalases, KatA and KatB, along with peroxiredoxin, AhpC in Pseudomonas putida. Hishinuma, S., Yuki, M., Fujimura, M., Fukumori, F. Environ. Microbiol. (2006) [Pubmed]
  3. Mutational Analysis To Define an Activating Region on the Redox-Sensitive Transcriptional Regulator OxyR. Wang, X., Mukhopadhyay, P., Wood, M.J., Outten, F.W., Opdyke, J.A., Storz, G. J. Bacteriol. (2006) [Pubmed]
  4. In vivo transcription of the Escherichia coli oxyR regulon as a function of growth phase and in response to oxidative stress. Michán, C., Manchado, M., Dorado, G., Pueyo, C. J. Bacteriol. (1999) [Pubmed]
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