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Gene Review

CG42637  -  CG42637 gene product from transcript...

Drosophila melanogaster

Synonyms: Dmel\CG42637, Dmel_CG8742
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High impact information on Gyc76C

  • In situ hybridizations to adult tissue sections showed that drgc mRNA is expressed in a wide range of tissues, including the optic lobe, central brain, thoracic ganglia, digestive tract, and the oocyte [1].
  • The other class of cDNA, drgc, maps to 76C and encodes a 1525-amino acid protein displaying structural features similar to other known receptor-type guanylate cyclases [1].
  • Additionally, we find that the integrity of the Gyc76C catalytic cyclase domain is critical for Gyc76C function in Sema-1a axon repulsion [2].
  • PcGC-M2 is most closely related (33% identity) to a Drosophila membrane form GC (DrGC-1), and an Anopheles gambiae membrane form GC (AgaGC); the three GCs also share a similar distribution pattern of conserved cysteine residues in the extracellular domain [3].


  1. Molecular characterization of two Drosophila guanylate cyclases expressed in the nervous system. Liu, W., Yoon, J., Burg, M., Chen, L., Pak, W.L. J. Biol. Chem. (1995) [Pubmed]
  2. The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion. Ayoob, J.C., Yu, H.H., Terman, J.R., Kolodkin, A.L. J. Neurosci. (2004) [Pubmed]
  3. Molecular cloning of a putative membrane form guanylyl cyclase from the crayfish Procambarus clarkii. Liu, H.F., Lai, C.Y., Watson, R.D., Lee, C.Y. J. Exp. Zoolog. Part A Comp. Exp. Biol. (2004) [Pubmed]
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