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Gene Review

TSHR  -  thyroid stimulating hormone receptor

Canis lupus familiaris

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Disease relevance of TSHR

  • Abnormalities in TSH-receptor binding such as a low receptor number or low binding affinity may be a marker of thyroid carcinoma or metastases, or may exhibit a relationship with the functional variability of such tissues [1].
  • When thyrocytes were pretreated with pertussis toxin (PTX), the TSH receptor-mediated accumulation of cAMP increased by approximately 45% with TSH at 1 mU/ml, suggesting that the TSH receptor coupled to both G(s) and G(i) in vivo [2].

High impact information on TSHR

  • Gs activation provoked a similar effect on LH receptor distribution in MDCK cells, whereas it did not modify the compartmentalization of the TSH receptor [3].
  • These data indicate that carbachol-induced inhibition of adenylyl cyclase occurs beyond the level of TSH receptor binding and that Gs is a possible site of its action [4].
  • Regulation of TSH receptor (TSHr) mRNA accumulation has been investigated in canine thyrocytes in primary culture by in situ hybridization experiments; the effects of the mitogenic thyrotropin (TSH), epidermal growth factor (EGF), and phorbol ester TPA (12-O-tetradecanoylphorbol-13-acetate) have been compared [5].
  • Plasma membrane preparations were assayed after treatment of primary cultured dog thyroid cells to determine the role of the TSH receptor, stimulatory and inhibitory guanine nucleotide binding proteins (Gs and Gi), and catalytic unit in AC desensitization [6].
  • Within 5-60 min of incubation of cell membranes with amiodarone, there were profound changes in adenylate cyclase activity and TSH receptor binding [7].

Anatomical context of TSHR

  • These results suggest that amiodarone has specific inhibitory effects on agonist-stimulated functions in thyroid cells, possibly by interfering with TSH-receptor interactions and also at the level of cholinergic receptors [7].

Associations of TSHR with chemical compounds


Other interactions of TSHR

  • The effect of acute administration of KI on the expression of four major thyroid genes, the TSH receptor (TSHr), thyroglobulin (Tg), thyroperoxidase (TPO), and Na+/I- symporter (NIS) was analyzed by Northern blot [9].

Analytical, diagnostic and therapeutic context of TSHR

  • The thyrotropin receptor (TSHR) was cloned by selective amplification with the polymerase chain reaction of DNA segments presenting sequence similarity with genes for G protein-coupled receptors [10].


  1. Thyrotrophin receptors in normal and neoplastic (primary and metastatic) canine thyroid tissue. Verschueren, C.P., Rutteman, G.R., Vos, J.H., Van Dijk, J.E., de Bruin, T.W. J. Endocrinol. (1992) [Pubmed]
  2. Multiple G-protein coupling of the dog thyrotropin receptor. Allgeier, A., Laugwitz, K.L., Van Sande, J., Schultz, G., Dumont, J.E. Mol. Cell. Endocrinol. (1997) [Pubmed]
  3. Basolateral localization and transcytosis of gonadotropin and thyrotropin receptors expressed in Madin-Darby canine kidney cells. Beau, I., Misrahi, M., Gross, B., Vannier, B., Loosfelt, H., Hai, M.T., Pichon, C., Milgrom, E. J. Biol. Chem. (1997) [Pubmed]
  4. Carbachol-induced decrease in thyroid cell adenylyl cyclase activity is independent of calcium and phosphodiesterase activation. Pasquali, D., Rani, C.S., Deery, W.J. Mol. Pharmacol. (1992) [Pubmed]
  5. Differential regulation of thyrotropin receptor and thyroglobulin mRNA accumulation at the cellular level: an in situ hybridization study. Pohl, V., Maenhaut, C., Gérard, C., Vassart, G., Dumont, J.E. Exp. Cell Res. (1992) [Pubmed]
  6. Protein kinase C activation mimics but does not mediate thyrotropin-induced desensitization of adenylyl cyclase in cultured dog thyroid cells. Deery, W.J., Rani, C.S. Endocrinology (1991) [Pubmed]
  7. Amiodarone effects on thyrotropin receptors and responses stimulated by thyrotropin and carbachol in cultured dog thyroid cells. Rani, C.S. Endocrinology (1990) [Pubmed]
  8. Effects of prostaglandins F alpha on dog thyroid cyclic AMP level and function. van Sande, J., Cochaux, P., Decoster, C., Boeynaems, J.M., Dumont, J.E. Biochim. Biophys. Acta (1982) [Pubmed]
  9. Moderate doses of iodide in vivo inhibit cell proliferation and the expression of thyroperoxidase and Na+/I- symporter mRNAs in dog thyroid. Uyttersprot, N., Pelgrims, N., Carrasco, N., Gervy, C., Maenhaut, C., Dumont, J.E., Miot, F. Mol. Cell. Endocrinol. (1997) [Pubmed]
  10. Molecular cloning of the thyrotropin receptor. Parmentier, M., Libert, F., Maenhaut, C., Lefort, A., Gérard, C., Perret, J., Van Sande, J., Dumont, J.E., Vassart, G. Science (1989) [Pubmed]
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