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Gene Review

RAB7A  -  RAB7A, member RAS oncogene family

Canis lupus familiaris

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High impact information on RAB7A

  • The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes [1].
  • The two late endosomal proteins, Rab9 and Rab7, were each recruited onto endosome membranes with approximate apparent Km values of 9 and 22 nM, respectively [2].
  • Since Rab7 and Rab9 are both localized at least in large part, to late endosomes, this suggests that a single organelle may bear multiple Rab recruitment machines [2].
  • A subset of the perinuclear vacuoles appeared to colocalize with the late endosomal GTPase, Rab7 [3].

Associations of RAB7A with chemical compounds


  1. The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes. Dong, J., Chen, W., Welford, A., Wandinger-Ness, A. J. Biol. Chem. (2004) [Pubmed]
  2. Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes. Soldati, T., Rancaño, C., Geissler, H., Pfeffer, S.R. J. Biol. Chem. (1995) [Pubmed]
  3. Microtubules are involved in bafilomycin A1-induced tubulation and Rab5-dependent vacuolation of early endosomes. D'Arrigo, A., Bucci, C., Toh, B.H., Stenmark, H. Eur. J. Cell Biol. (1997) [Pubmed]
  4. Fluid-phase markers in the basolateral endocytic pathway accumulate in response to the actin assembly-promoting drug Jasplakinolide. Shurety, W., Stewart, N.L., Stow, J.L. Mol. Biol. Cell (1998) [Pubmed]
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