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Gene Review

RAB7A  -  RAB7A, member RAS oncogene family

Homo sapiens

Synonyms: PRO2706, RAB7, Ras-related protein Rab-7a
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Disease relevance of RAB7A


Psychiatry related information on RAB7A

  • PSN was associated with significantly lower scores (i.e., worse quality of life) in the mental health scale; CAD was associated with significant reductions of all but role-emotional and mental health scales of the SF-36; and PVD was associated with significantly lower physical and social functioning scales [6].
  • A set of problem solving strategies integrated into nursing process in nursing core courses (PSNP) was developed for students enrolled in a post-RN baccalaureate nursing program (RN-BSN) in a university in Taiwan. The purpose of this study, therefore, was to evaluate the effectiveness of PSNP on students' clinical problem solving abilities [7].

High impact information on RAB7A

  • Fusion could be inhibited by cytosol containing the overexpressed mutant rab5lle133, which does not bind GTP on blots, and by antibodies against rab5, but not against rab2 or rab7 [8].
  • The second, rab5, is located at the cytoplasmic surface of the plasma membrane and on early endosomes, while the third, rab7, is found on late endosomes [9].
  • To define the region mediating their specific localization, we transiently expressed rab2, rab5 and rab7 hybrid proteins in BHK cells, and determined their intracellular localization by immunofluorescence confocal microscopy and subcellular fractionation [10].
  • A role for rab7 GTPase in growth factor-regulated cell nutrition and apoptosis [11].
  • Our results demonstrate a role for Rab7 and Rab9 in the Golgi targeting of glycosphingolipids and suggest a new therapeutic approach for restoring normal lipid trafficking in NP-C cells [12].

Chemical compound and disease context of RAB7A


Biological context of RAB7A


Anatomical context of RAB7A

  • RAB7 is ubiquitously expressed, and we found expression in sensory and motor neurons [14].
  • Recently two genes, RAB38 and RAB7, were reported to play an important role in melanogenesis in the melanocyte, suggesting that these two genes could be good candidates for new OCA loci [17].
  • RILP-C33 (a truncated form of the protein lacking the N-terminal half) strongly inhibits epidermal growth factor and low-density lipoprotein degradation, and causes dispersion of lysosomes similarly to Rab7 dominant-negative mutants [18].
  • Furthermore, when inhibitory mutants of rab7 are expressed, the internalized EGF.EGFR complex accumulates in high-density endosomes that are characteristic of the late endocytic pathway [19].
  • We have now used a new approach to analyze the role of Rab7: transient expression of Enhanced Green Fluorescent Protein (EGFP)-tagged Rab7 wt and mutant proteins in HeLa cells [16].

Associations of RAB7A with chemical compounds

  • Sequencing the RAB7 gene showed a novel heterozygous A to C mutation, changing asparagine to threonine at codon 161 [1].
  • The mutation is situated adjacent to a previously identified valine to methionine mutation at codon 162, implying a hotspot for mutations in the highly conserved C terminus of RAB7 [1].
  • The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production [5].
  • This could also be overcome by the addition of ascorbate, which induced formation of anMan-positive degradation products that colocalized with Rab7 [13].
  • Rab5 and Rab7 Control Endocytic Sorting along the Axonal Retrograde Transport Pathway [20].

Physical interactions of RAB7A


Co-localisations of RAB7A


Regulatory relationships of RAB7A

  • We propose that the departure of SNX5-positive tubules represents a rapid mechanism of recycling components from macropinosomes thereby promoting their maturation into Rab7-positive structures [24].
  • RILP has a key role in the control of transport to degradative compartments together with Rab7 and probably links Rab7 function to the cytoskeleton [25].

Other interactions of RAB7A

  • All these data are consistent with a model in which RILP represents a downstream effector for Rab7 and both proteins act together in the regulation of late endocytic traffic [18].
  • In contrast, after ingestion, dead bacteria colocalized with late endosome marker Rab7, and lysosome markers LAMP1 and cathepsin D, but not with calnexin or MDC [26].
  • Staphylococci-containing phagosomes were matured by sequential and dynamic interactions with Rab5- and Rab7-positive vesicles [27].
  • Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA [17].
  • ORP1L localizes to late endosomes (LEs)/lysosomes, colocalizing with the GTPases Rab7 and Rab9 and lysosome-associated membrane protein-1 [2].

Analytical, diagnostic and therapeutic context of RAB7A


  1. A novel RAB7 mutation associated with ulcero-mutilating neuropathy. Houlden, H., King, R.H., Muddle, J.R., Warner, T.T., Reilly, M.M., Orrell, R.W., Ginsberg, L. Ann. Neurol. (2004) [Pubmed]
  2. The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments. Johansson, M., Lehto, M., Tanhuanpää, K., Cover, T.L., Olkkonen, V.M. Mol. Biol. Cell (2005) [Pubmed]
  3. The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein. Harada, M., Kawaguchi, T., Kumemura, H., Terada, K., Ninomiya, H., Taniguchi, E., Hanada, S., Baba, S., Maeyama, M., Koga, H., Ueno, T., Furuta, K., Suganuma, T., Sugiyama, T., Sata, M. Am. J. Pathol. (2005) [Pubmed]
  4. In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex. Rak, A., Niculae, A., Kalinin, A., Thomä, N.H., Sidorovitch, V., Goody, R.S., Alexandrov, K. Protein Expr. Purif. (2002) [Pubmed]
  5. The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production. Croizet-Berger, K., Daumerie, C., Couvreur, M., Courtoy, P.J., van den Hove, M.F. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Impact of long-term complications on quality of life in patients with type 2 diabetes not using insulin. Lloyd, A., Sawyer, W., Hopkinson, P. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. (2001) [Pubmed]
  7. Problem solving strategies integrated into nursing process to promote clinical problem solving abilities of RN-BSN students. Wang, J.J., Lo, C.H., Ku, Y.L. Nurse education today. (2004) [Pubmed]
  8. rab5 controls early endosome fusion in vitro. Gorvel, J.P., Chavrier, P., Zerial, M., Gruenberg, J. Cell (1991) [Pubmed]
  9. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Chavrier, P., Parton, R.G., Hauri, H.P., Simons, K., Zerial, M. Cell (1990) [Pubmed]
  10. Hypervariable C-terminal domain of rab proteins acts as a targeting signal. Chavrier, P., Gorvel, J.P., Stelzer, E., Simons, K., Gruenberg, J., Zerial, M. Nature (1991) [Pubmed]
  11. A role for rab7 GTPase in growth factor-regulated cell nutrition and apoptosis. Snider, M.D. Mol. Cell (2003) [Pubmed]
  12. Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells. Choudhury, A., Dominguez, M., Puri, V., Sharma, D.K., Narita, K., Wheatley, C.L., Marks, D.L., Pagano, R.E. J. Clin. Invest. (2002) [Pubmed]
  13. Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes. Mani, K., Cheng, F., Fransson, L.A. Glycobiology (2006) [Pubmed]
  14. Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. Verhoeven, K., De Jonghe, P., Coen, K., Verpoorten, N., Auer-Grumbach, M., Kwon, J.M., FitzPatrick, D., Schmedding, E., De Vriendt, E., Jacobs, A., Van Gerwen, V., Wagner, K., Hartung, H.P., Timmerman, V. Am. J. Hum. Genet. (2003) [Pubmed]
  15. NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukemia and deleted in solid tumors. Kashuba, V.I., Gizatullin, R.Z., Protopopov, A.I., Allikmets, R., Korolev, S., Li, J., Boldog, F., Tory, K., Zabarovska, V., Marcsek, Z., Sumegi, J., Klein, G., Zabarovsky, E.R., Kisselev, L. FEBS Lett. (1997) [Pubmed]
  16. Rab7: a key to lysosome biogenesis. Bucci, C., Thomsen, P., Nicoziani, P., McCarthy, J., van Deurs, B. Mol. Biol. Cell (2000) [Pubmed]
  17. Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA. Suzuki, T., Miyamura, Y., Inagaki, K., Tomita, Y. J. Dermatol. Sci. (2003) [Pubmed]
  18. Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. Cantalupo, G., Alifano, P., Roberti, V., Bruni, C.B., Bucci, C. EMBO J. (2001) [Pubmed]
  19. rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome. Ceresa, B.P., Bahr, S.J. J. Biol. Chem. (2006) [Pubmed]
  20. Rab5 and Rab7 Control Endocytic Sorting along the Axonal Retrograde Transport Pathway. Deinhardt, K., Salinas, S., Verastegui, C., Watson, R., Worth, D., Hanrahan, S., Bucci, C., Schiavo, G. Neuron (2006) [Pubmed]
  21. Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1. Rak, A., Pylypenko, O., Niculae, A., Goody, R.S., Alexandrov, K. J. Struct. Biol. (2003) [Pubmed]
  22. The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction. Colucci, A.M., Campana, M.C., Bellopede, M., Bucci, C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  23. Human VPS34 and p150 are Rab7 interacting partners. Stein, M.P., Feng, Y., Cooper, K.L., Welford, A.M., Wandinger-Ness, A. Traffic (2003) [Pubmed]
  24. Visualisation of macropinosome maturation by the recruitment of sorting nexins. Kerr, M.C., Lindsay, M.R., Luetterforst, R., Hamilton, N., Simpson, F., Parton, R.G., Gleeson, P.A., Teasdale, R.D. J. Cell. Sci. (2006) [Pubmed]
  25. Expression analysis and chromosomal assignment of PRA1 and RILP genes. Bucci, C., De Gregorio, L., Bruni, C.B. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  26. Intracellular trafficking and replication of Burkholderia cenocepacia in human cystic fibrosis airway epithelial cells. Sajjan, U.S., Yang, J.H., Hershenson, M.B., LiPuma, J.J. Cell. Microbiol. (2006) [Pubmed]
  27. Live cell imaging of phagosome maturation in Staphylococcus aureus infected human endothelial cells: small colony variants are able to survive in lysosomes. Schr??der, A., Kland, R., Peschel, A., von Eiff, C., Aepfelbacher, M. Med. Microbiol. Immunol. (Berl.) (2006) [Pubmed]
  28. Rab4 and Rab7 define distinct nonoverlapping endosomal compartments. Bottger, G., Nagelkerken, B., van der Sluijs, P. J. Biol. Chem. (1996) [Pubmed]
  29. Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro. Alexandrov, K., Heinemann, I., Durek, T., Sidorovitch, V., Goody, R.S., Waldmann, H. J. Am. Chem. Soc. (2002) [Pubmed]
  30. The K1 capsule modulates trafficking of E. coli-containing vacuoles and enhances intracellular bacterial survival in human brain microvascular endothelial cells. Kim, K.J., Elliott, S.J., Di Cello, F., Stins, M.F., Kim, K.S. Cell. Microbiol. (2003) [Pubmed]
  31. Assays for interaction between Rab7 and oxysterol binding protein related protein 1L (ORP1L). Johansson, M., Olkkonen, V.M. Meth. Enzymol. (2005) [Pubmed]
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