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Gene Review

Rab7a  -  RAB7A, member RAS oncogene family

Rattus norvegicus

Synonyms: Rab7, Ras-related protein BRL-RAS, Ras-related protein Rab-7a, Ras-related protein p23
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Disease relevance of Rab7


High impact information on Rab7

  • We demonstrate further that Rab7 colocalizes with Rac1 at the fusion zone of the ruffled border in bone-resorbing osteoclasts [3].
  • Possible role of direct Rac1-Rab7 interaction in ruffled border formation of osteoclasts [3].
  • As compared with early vesicles, late vesicles had reduced association with receptor, Rab4, and kinesin I but were highly associated with dynein, Rab7, dynactin, and KIF3A [4].
  • TNF-alpha stimulated the colocalization of GD3 with early and late endosomal markers, Rab 5 and Rab 7, whereas perturbation of plasma membrane cholesterol or actin cytoskeleton or inhibition of glucosylceramide synthase prevented the trafficking of GD3 to mitochondria [5].
  • Here we show that Rab7, a small GTPase that is associated with late endosomes, is highly expressed and is predominantly localized at the ruffled border in bone-resorbing osteoclasts [1].

Anatomical context of Rab7

  • The decreased expression of Rab7 in cultured osteoclasts by antisense oligodeoxynucleotides disrupted the polarization of the osteoclasts and the targeting of vesicles to the ruffled border [1].
  • Because Rac1 is known to control the actin cytoskeleton through its effectors, the Rab7-Rac1 interaction may mediate late endosomal transport between microtubules and microfilaments enabling endosomal vesicles to switch tracks and may thus also regulate ruffled border formation in osteoclasts [3].
  • Internalized SP-A cannot be resecreted rapidly to plasma membrane, and lipid is not transported toward late endosomes (Rab7- and M6PR-positive) or lamellar bodies (CD63- and 3C9-positive) [6].
  • Here we report that depletion of intracellular mevalonate by lovastatin in FRTL-5 thyroid cells specifically resulted in a four-fold increase of Rab5 and Rab7 protein levels [7].
  • Our studies show that the endosomal GTPase Rab7 controls the endosomal trafficking and neurite outgrowth signaling of TrkA [2].

Other interactions of Rab7

  • Identification of Rab GTPases 4, 5, 18, and 21 (associated with early endosomes); Rab7 (late endosomes); and Rab11 and Rab25 (recycling endosomes) indicate that a substantial fraction of intracellular AQP2 is present in endosomal compartments [8].

Analytical, diagnostic and therapeutic context of Rab7

  • The effects of IL-4 and IL-13 were accompanied by redistribution of the small GTPases Rab5b and Rab7, as shown by confocal immunofluorescence studies [9].


  1. Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption. Zhao, H., Laitala-Leinonen, T., Parikka, V., Väänänen, H.K. J. Biol. Chem. (2001) [Pubmed]
  2. The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA. Saxena, S., Bucci, C., Weis, J., Kruttgen, A. J. Neurosci. (2005) [Pubmed]
  3. Possible role of direct Rac1-Rab7 interaction in ruffled border formation of osteoclasts. Sun, Y., Büki, K.G., Ettala, O., Vääräniemi, J.P., Väänänen, H.K. J. Biol. Chem. (2005) [Pubmed]
  4. Microtubule-dependent movement of late endocytic vesicles in vitro: requirements for Dynein and Kinesin. Bananis, E., Nath, S., Gordon, K., Satir, P., Stockert, R.J., Murray, J.W., Wolkoff, A.W. Mol. Biol. Cell (2004) [Pubmed]
  5. Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha. García-Ruiz, C., Colell, A., Morales, A., Calvo, M., Enrich, C., Fernández-Checa, J.C. J. Biol. Chem. (2002) [Pubmed]
  6. Chlamydia pneumoniae affect surfactant trafficking and secretion due to changes of type II cell cytoskeleton. Wissel, H., Schulz, C., Rüdiger, M., Krüll, M., Stevens, P.A., Wauer, R.R. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  7. Control of Rab5 and Rab7 expression by the isoprenoid pathway. Laezza, C., Bucci, C., Santillo, M., Bruni, C.B., Bifulco, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  8. Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct. Barile, M., Pisitkun, T., Yu, M.J., Chou, C.L., Verbalis, M.J., Shen, R.F., Knepper, M.A. Mol. Cell Proteomics (2005) [Pubmed]
  9. Interleukin-4 and -13 promote basolateral secretion of H(+) and cathepsin L by glomerular epithelial cells. Van Den Berg, J.G., Aten, J., Annink, C., Ravesloot, J.H., Weber, E., Weening, J.J. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
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