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Gene Review

runx2b  -  runt-related transcription factor 2b

Danio rerio

Synonyms: SO:0000704
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High impact information on runx2b


Anatomical context of runx2b

  • Because runx2b expression was abolished in Runx3 morphants, we propose that endodermal Runx3 has a role in influencing signaling activities from the endoderm to promote chondrocyte differentiation [2].

Other interactions of runx2b

  • To explore the differentiation of skeletogenic cells in the model organism zebrafish (Danio rerio), we have identified two orthologues of the mammalian gene, runx2a and runx2b [4].

Analytical, diagnostic and therapeutic context of runx2b


  1. Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. Pinto, J.P., Conceição, N.M., Viegas, C.S., Leite, R.B., Hurst, L.D., Kelsh, R.N., Cancela, M.L. J. Bone Miner. Res. (2005) [Pubmed]
  2. A hierarchy of Runx transcription factors modulate the onset of chondrogenesis in craniofacial endochondral bones in zebrafish. Flores, M.V., Lam, E.Y., Crosier, P., Crosier, K. Dev. Dyn. (2006) [Pubmed]
  3. An essential role for zebrafish Fgfrl1 during gill cartilage development. Hall, C., Flores, M.V., Murison, G., Crosier, K., Crosier, P. Mech. Dev. (2006) [Pubmed]
  4. Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements. Flores, M.V., Tsang, V.W., Hu, W., Kalev-Zylinska, M., Postlethwait, J., Crosier, P., Crosier, K., Fisher, S. Gene Expr. Patterns (2004) [Pubmed]
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