High impact information on runx2b

• Zebrafish runx2b has two promoter regions separated by a large intron [1].
• The runx2b pebp2alphaA2 isoform induces osteocalcin gene expression by binding to a specific region of the promoter and seems to have been selectively conserved in the teleost lineage [1].
• Sequence analysis suggested that the runx2b gene encodes three distinct isoforms, by a combination of alternative splicing and differential promoter activation, as described for the human gene [1].
• Depletion of runx2b (but not runx2a) and runx3 severely compromised craniofacial cartilage formation [2].
• In addition, two transcription factors essential for chondrogenesis, sox9a and runx2b, fail to express within the mesenchymal condensations of the branchial arches [3].

Anatomical context of runx2b

• Because runx2b expression was abolished in Runx3 morphants, we propose that endodermal Runx3 has a role in influencing signaling activities from the endoderm to promote chondrocyte differentiation [2].

Other interactions of runx2b

• To explore the differentiation of skeletogenic cells in the model organism zebrafish (Danio rerio), we have identified two orthologues of the mammalian gene, runx2a and runx2b [4].

Analytical, diagnostic and therapeutic context of runx2b

• MATERIALS AND METHODS: Zebrafish runx2b gene and cDNA were isolated by RT-PCR and sequence data mining [1].

References