High impact information on runx3

• The earliest expression detected was that of runx3 in the pharyngeal endoderm, then runx2a and b in mesenchymal condensations, and later runx1 in the epithelium [1].
• Depletion of runx2b (but not runx2a) and runx3 severely compromised craniofacial cartilage formation [1].
• Hematopoietic expression of runx3 commences late in embryogenesis in the ventral tail intermediate cell mass and later colocalizes with spi1 and lyz in circulating blood cells [2].
• We cloned zebrafish runx3/aml2/cbfa3 and examined its expression and function during embryogenesis [2].
• Neuronal tissues expressing runx3 include the trigeminal ganglia and Rohon-Beard neurons [2].

Anatomical context of runx3

• Conversely, ubiquitous overexpression of runx3 led to an increase in primitive blood cell numbers, together with an increase in runx1-expressing cells in the ventral wall of the dorsal aorta [2].

Other interactions of runx3

• Zebrafish runx2 is duplicated, but not runx1 or runx3 [1].

References