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Gene Review

rn  -  rotund

Drosophila melanogaster

Synonyms: 5.3, CG10040, CG14600, CG14601, CG14603, ...
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High impact information on rn

  • The rotund (rn) mutation in Drosophila is unique in that its phenotype is limited to the deletion of specific distal parts, though not the extremities, of all adult appendages [1].
  • We have cloned the rn gene, located at cytogenetic position 84D3,4, by chromosomal walking [1].
  • Flagellar growth continued within the short rn null cysts to produce large bulbous terminations of intertwined mature flagella [2].
  • Our analysis of rotund (rn) null mutations in Drosophila melanogaster revealed that deletion of the rn locus affects both spermatid and retinal differentiation [2].
  • Control of Drosophila imaginal disc development by rotund and roughened eye: differentially expressed transcripts of the same gene encoding functionally distinct zinc finger proteins [3].

Biological context of rn

  • The rotund (rn) locus of Drosophila melanogaster at cytogenetic position 84D3,4 has been isolated and cloned on the basis of the mutant phenotype: an absence of structures in the subdistal regions of the appendages [4].
  • The DNA sequencing of the cloned 5.3 kb element revealed that Tirant possesses an open reading frame (ORF) that shows similarity with the envelope protein encoded by the gypsy and 297 retrotransposons [5].
  • The 5.3 kb element present in the fs(2) PM11-19 mt-gs allele possesses a 417 bp long terminal repeat (LTR) at both ends [5].

Associations of rn with chemical compounds

  • Circular dichroism spectroscopy, used to monitor thermal denaturations of a heterodimerizing leucine zipper system containing either valine (V) or asparagine (N) in the 'a' position, indicates that the V-N interaction is 2.3 kcal/mole less stable than an N-N interaction and 5.3 kcal/mole less stable than a V-V interaction [6].
  • In vitro synthesized MET directly bound to JH III with high affinity (Kd = 5.3 +/- 1.5 nm, mean +/- SD), consistent with the physiological JH concentration [7].

Physical interactions of rn

  • We also showed by pull-down assays that Nab binds directly to Rotund and Squeeze via its conserved C-terminal domain [8].

Other interactions of rn


Analytical, diagnostic and therapeutic context of rn

  • Previous sequence analysis of rn genomic DNA and incomplete cDNA clones suggested that at least two differentially spliced forms of the transcript exist, rnRacGAP(1) and rnRacGAP(2) [9].


  1. Two transcripts from the rotund region of Drosophila show similar positional specificities in imaginal disc tissues. Agnel, M., Kerridge, S., Vola, C., Griffin-Shea, R. Genes Dev. (1989) [Pubmed]
  2. RotundRacGAP functions with Ras during spermatogenesis and retinal differentiation in Drosophila melanogaster. Bergeret, E., Pignot-Paintrand, I., Guichard, A., Raymond, K., Fauvarque, M.O., Cazemajor, M., Griffin-Shea, R. Mol. Cell. Biol. (2001) [Pubmed]
  3. Control of Drosophila imaginal disc development by rotund and roughened eye: differentially expressed transcripts of the same gene encoding functionally distinct zinc finger proteins. St Pierre, S.E., Galindo, M.I., Couso, J.P., Thor, S. Development (2002) [Pubmed]
  4. A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins. Agnel, M., Röder, L., Vola, C., Griffin-Shea, R. Mol. Cell. Biol. (1992) [Pubmed]
  5. Cloning and characterization of a copy of Tirant transposable element in Drosophila melanogaster. Viggiano, L., Caggese, C., Barsanti, P., Caizzi, R. Gene (1997) [Pubmed]
  6. B-ZIP proteins encoded by the Drosophila genome: evaluation of potential dimerization partners. Fassler, J., Landsman, D., Acharya, A., Moll, J.R., Bonovich, M., Vinson, C. Genome Res. (2002) [Pubmed]
  7. Characterization of the Drosophila Methoprene -tolerant gene product. Juvenile hormone binding and ligand-dependent gene regulation. Miura, K., Oda, M., Makita, S., Chinzei, Y. FEBS J. (2005) [Pubmed]
  8. Nab controls the activity of the zinc-finger transcription factors Squeeze and Rotund in Drosophila development. Terriente Félix, J., Magariños, M., Díaz-Benjumea, F.J. Development (2007) [Pubmed]
  9. Alternative splicing of the Drosophila melanogaster rotundRacGAP gene. Hoemann, C.D., Bergeret, E., Guichard, A., Griffin-Shea, R. Gene (1996) [Pubmed]
  10. Identification and characterization of autosomal genes that interact with glass in the developing Drosophila eye. Ma, C., Liu, H., Zhou, Y., Moses, K. Genetics (1996) [Pubmed]
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