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Gene Review

RacGAP84C  -  Rac GTPase activating protein at 84C

Drosophila melanogaster

Synonyms: CG2595, Dmel\CG2595, GAP84C, GTPase-activating protein RacGAP84C, P1.7, ...
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Disease relevance of RacGAP84C

  • Since rotundRacGAP deletion leads to male sterility in the fruit fly, the mgcRacGAP gene may prove likewise to play a key role in mammalian male fertility [1].

Psychiatry related information on RacGAP84C


High impact information on RacGAP84C


Biological context of RacGAP84C


Anatomical context of RacGAP84C


Physical interactions of RacGAP84C

  • Similarly, in yeast, RotundRacGAP interacts specifically with Drac1 and Dcdc42, as well as with their activated V12 forms, showing a particularly strong interaction with Dcdc42V12 [7].

Regulatory relationships of RacGAP84C

  • To examine RnRacGAP function, we generated transgenic strains expressing RnRacGAP under the control of the heat-shock promoter hsp70 [2].

Other interactions of RacGAP84C


  1. MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. Touré, A., Dorseuil, O., Morin, L., Timmons, P., Jégou, B., Reibel, L., Gacon, G. J. Biol. Chem. (1998) [Pubmed]
  2. Overexpression of RnRacGAP in Drosophila melanogaster deregulates cytoskeletal organisation in cellularising embryos and induces discrete imaginal phenotypes. Guichard, A., Bergeret, E., Griffin-Shea, R. Mech. Dev. (1997) [Pubmed]
  3. RotundRacGAP functions with Ras during spermatogenesis and retinal differentiation in Drosophila melanogaster. Bergeret, E., Pignot-Paintrand, I., Guichard, A., Raymond, K., Fauvarque, M.O., Cazemajor, M., Griffin-Shea, R. Mol. Cell. Biol. (2001) [Pubmed]
  4. A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins. Agnel, M., Röder, L., Vola, C., Griffin-Shea, R. Mol. Cell. Biol. (1992) [Pubmed]
  5. Control of Drosophila imaginal disc development by rotund and roughened eye: differentially expressed transcripts of the same gene encoding functionally distinct zinc finger proteins. St Pierre, S.E., Galindo, M.I., Couso, J.P., Thor, S. Development (2002) [Pubmed]
  6. Alternative splicing of the Drosophila melanogaster rotundRacGAP gene. Hoemann, C.D., Bergeret, E., Guichard, A., Griffin-Shea, R. Gene (1996) [Pubmed]
  7. The Rac GTPase-activating protein RotundRacGAP interferes with Drac1 and Dcdc42 signalling in Drosophila melanogaster. Raymond, K., Bergeret, E., Dagher, M.C., Breton, R., Griffin-Shea, R., Fauvarque, M.O. J. Biol. Chem. (2001) [Pubmed]
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