Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

TfIIFbeta - Transcription factor TFIIFbeta

Drosophila melanogaster

Synonyms: ATP-dependent helicase TfIIF-beta, CG6538, Dmel\CG6538, F[[S]], General transcription factor IIF subunit 2, ...

Kephart, D.D. et al., Frank, D.J. et al., Li, C. et al., Tan, S. et al., Gong, D.W. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TfIIFbeta

The protein encoded by the cDNA, termed dTFIIF30, was synthesized in Escherichia coli and purified to greater than 95% homogeneity [1].

High impact information on TfIIFbeta

We first compared Eve activities in in vitro transcription systems reconstituted with either all the general transcription factors or only TBP, TFIIB, TFIIF30, and RNA polymerase II [2].
It has been suggested that 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits RNA polymerase II during elongation, but we find that the purine nucleoside analog has no effect on elongation complexes containing RNA over 500 nucleotides in length or on the action of factor 5 or DmS-II in the defined system [3].
The Drosophila TFIIF30 gene is located at region 86C on the right arm of the third chromosome [1].

Analytical, diagnostic and therapeutic context of TfIIFbeta

Dissection of transcription factor TFIIF functional domains required for initiation and elongation [4].
We report here the molecular cloning of a Drosophila cDNA encoding TFIIF beta [5].

References

Structure and function of the small subunit of TFIIF (RAP30) from Drosophila melanogaster. Frank, D.J., Tyree, C.M., George, C.P., Kadonaga, J.T. J. Biol. Chem. (1995) [Pubmed]
Even-skipped represses transcription by binding TATA binding protein and blocking the TFIID-TATA box interaction. Li, C., Manley, J.L. Mol. Cell. Biol. (1998) [Pubmed]
Stability of Drosophila RNA polymerase II elongation complexes in vitro. Kephart, D.D., Marshall, N.F., Price, D.H. Mol. Cell. Biol. (1992) [Pubmed]
Dissection of transcription factor TFIIF functional domains required for initiation and elongation. Tan, S., Conaway, R.C., Conaway, J.W. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
Molecular cloning of cDNA encoding the small subunit of Drosophila transcription initiation factor TFIIF. Gong, D.W., Mortin, M.A., Horikoshi, M., Nakatani, Y. Nucleic Acids Res. (1995) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP007002	Anopheles gambiae str. PEST
GTF2F2	Bos taurus
CELE_Y39B6A.36	Caenorhabditis elegans
GTF2F2	Canis lupus familiaris
gtf2f2a	Danio rerio
GTF2F2	Gallus gallus
GTF2F2	Homo sapiens
GTF2F2	Macaca mulatta
Gtf2f2	Mus musculus
GTF2F2	Pan troglodytes
Gtf2f2	Rattus norvegicus
gtf2f2	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.