The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TfIIS  -  RNA polymerase II elongation factor

Drosophila melanogaster

Synonyms: BG:DS00929.12, CG3710, DmS-II, DmSII, Dmel\CG3710, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on TfIIS


Biological context of TfIIS


Associations of TfIIS with chemical compounds

  • DmS-II stimulates RNA polymerase II during the transcription of double-stranded DNA templates when the nonphysiological divalent cation manganese is present [8].
  • Analysis of pyrophosphorolysis on soluble or immobilized and templates confirmed that NTPs are liberated instead of dinucleotides that are released during DmS-II-mediated transcript cleavage [9].
  • During elongation, C4 and wild type responded similarly to DmS-II and NH4+ whereas the S1 mutant was less responsive to both [5].

Regulatory relationships of TfIIS


Other interactions of TfIIS


Analytical, diagnostic and therapeutic context of TfIIS


  1. dELL is an essential RNA polymerase II elongation factor with a general role in development. Eissenberg, J.C., Ma, J., Gerber, M.A., Christensen, A., Kennison, J.A., Shilatifard, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development. Gerber, M., Eissenberg, J.C., Kong, S., Tenney, K., Conaway, J.W., Conaway, R.C., Shilatifard, A. Mol. Cell. Biol. (2004) [Pubmed]
  3. Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A. Gerber, M., Tenney, K., Conaway, J.W., Conaway, R.C., Eissenberg, J.C., Shilatifard, A. J. Biol. Chem. (2005) [Pubmed]
  4. The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C. Brower, C.S., Shilatifard, A., Mather, T., Kamura, T., Takagi, Y., Haque, D., Treharne, A., Foundling, S.I., Conaway, J.W., Conaway, R.C. J. Biol. Chem. (1999) [Pubmed]
  5. Drosophila RNA polymerase II mutants that affect transcription elongation. Chen, Y., Chafin, D., Price, D.H., Greenleaf, A.L. J. Biol. Chem. (1996) [Pubmed]
  6. Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Eissenberg, J.C., Shilatifard, A., Dorokhov, N., Michener, D.E. Mol. Genet. Genomics (2007) [Pubmed]
  7. Promoter analysis of the Drosophila melanogaster gene encoding transcription elongation factor TFIIS. Oh, Y., Lee, S., Yoon, J., Han, K., Baek, K. Biochim. Biophys. Acta (2001) [Pubmed]
  8. Properties of a Drosophila RNA polymerase II elongation factor. Sluder, A.E., Greenleaf, A.L., Price, D.H. J. Biol. Chem. (1989) [Pubmed]
  9. Action of alpha-amanitin during pyrophosphorolysis and elongation by RNA polymerase II. Chafin, D.R., Guo, H., Price, D.H. J. Biol. Chem. (1995) [Pubmed]
  10. Drosophila RNA polymerase II elongation factor DmS-II has homology to mouse S-II and sequence similarity to yeast PPR2. Marshall, T.K., Guo, H., Price, D.H. Nucleic Acids Res. (1990) [Pubmed]
  11. Isolation and characterization of the gene encoding the Drosophila melanogaster transcriptional elongation factor, TFIIS. Oh, Y., Yoon, J., Baek, K. Biochim. Biophys. Acta (1995) [Pubmed]
  12. Identification and purification of a yeast protein that affects elongation by RNA polymerase II. Chafin, D.R., Claussen, T.J., Price, D.H. J. Biol. Chem. (1991) [Pubmed]
WikiGenes - Universities