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TfIIS  -  RNA polymerase II elongation factor

Drosophila melanogaster

Synonyms: BG:DS00929.12, CG3710, DmS-II, DmSII, Dmel\CG3710, ...
 
 
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High impact information on TfIIS

 

Biological context of TfIIS

 

Associations of TfIIS with chemical compounds

  • DmS-II stimulates RNA polymerase II during the transcription of double-stranded DNA templates when the nonphysiological divalent cation manganese is present [8].
  • Analysis of pyrophosphorolysis on soluble or immobilized and templates confirmed that NTPs are liberated instead of dinucleotides that are released during DmS-II-mediated transcript cleavage [9].
  • During elongation, C4 and wild type responded similarly to DmS-II and NH4+ whereas the S1 mutant was less responsive to both [5].
 

Regulatory relationships of TfIIS

 

Other interactions of TfIIS

 

Analytical, diagnostic and therapeutic context of TfIIS

References

  1. dELL is an essential RNA polymerase II elongation factor with a general role in development. Eissenberg, J.C., Ma, J., Gerber, M.A., Christensen, A., Kennison, J.A., Shilatifard, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development. Gerber, M., Eissenberg, J.C., Kong, S., Tenney, K., Conaway, J.W., Conaway, R.C., Shilatifard, A. Mol. Cell. Biol. (2004) [Pubmed]
  3. Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A. Gerber, M., Tenney, K., Conaway, J.W., Conaway, R.C., Eissenberg, J.C., Shilatifard, A. J. Biol. Chem. (2005) [Pubmed]
  4. The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C. Brower, C.S., Shilatifard, A., Mather, T., Kamura, T., Takagi, Y., Haque, D., Treharne, A., Foundling, S.I., Conaway, J.W., Conaway, R.C. J. Biol. Chem. (1999) [Pubmed]
  5. Drosophila RNA polymerase II mutants that affect transcription elongation. Chen, Y., Chafin, D., Price, D.H., Greenleaf, A.L. J. Biol. Chem. (1996) [Pubmed]
  6. Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Eissenberg, J.C., Shilatifard, A., Dorokhov, N., Michener, D.E. Mol. Genet. Genomics (2007) [Pubmed]
  7. Promoter analysis of the Drosophila melanogaster gene encoding transcription elongation factor TFIIS. Oh, Y., Lee, S., Yoon, J., Han, K., Baek, K. Biochim. Biophys. Acta (2001) [Pubmed]
  8. Properties of a Drosophila RNA polymerase II elongation factor. Sluder, A.E., Greenleaf, A.L., Price, D.H. J. Biol. Chem. (1989) [Pubmed]
  9. Action of alpha-amanitin during pyrophosphorolysis and elongation by RNA polymerase II. Chafin, D.R., Guo, H., Price, D.H. J. Biol. Chem. (1995) [Pubmed]
  10. Drosophila RNA polymerase II elongation factor DmS-II has homology to mouse S-II and sequence similarity to yeast PPR2. Marshall, T.K., Guo, H., Price, D.H. Nucleic Acids Res. (1990) [Pubmed]
  11. Isolation and characterization of the gene encoding the Drosophila melanogaster transcriptional elongation factor, TFIIS. Oh, Y., Yoon, J., Baek, K. Biochim. Biophys. Acta (1995) [Pubmed]
  12. Identification and purification of a yeast protein that affects elongation by RNA polymerase II. Chafin, D.R., Claussen, T.J., Price, D.H. J. Biol. Chem. (1991) [Pubmed]
 
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