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Gene Review

ARSF  -  arylsulfatase F

Homo sapiens

Synonyms: ASF, Arylsulfatase F
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Disease relevance of ARSF

  • Expression of the ARSF cDNA in COS cells resulted in a heat-labile arylsulfatase activity that is not inhibited by warfarin, supporting our hypothesis that only ARSE is specifically inhibited by warfarin and is most likely involved in warfarin embryopathy [1].
  • The E. coli strain bearing such ASF-shortened ribosomes had a normal growth rate but enhanced +1 frameshift activity [2].

High impact information on ARSF

  • Thus, the higher translational activity of ASF-shortened ribosomes is caused by the disruption of bridge B1a and is not due to weakened subunit association [2].
  • These observations indicate that the intrinsic translocation activity of ribosomes is greater than that usually observed in the WT ribosome and that ASF is a functional attenuator for translocation that serves to maintain the reading frame [2].
  • Cryptic splice site usage in exon 7 of the human fibrinogen Bbeta-chain gene is regulated by a naturally silent SF2/ASF binding site within this exon [3].
  • These findings, besides confirming and extending previous results regarding the effect of SF2/ASF on cryptic splice site activation, identify for the first time an enhancer sequence in the FGB gene specific for cryptic splice site usage [3].
  • 3. We have used a combined approach of long-range genomic sequencing and screening of cDNA libraries to isolate the ARSF gene [1].

Biological context of ARSF


Associations of ARSF with chemical compounds

  • ASF-shortened ribosomes showed normal subunit association but higher activity in poly(U)-dependent polyphenylalanine synthesis than the wild type (WT) ribosome at limited EF-G concentrations [2].


  1. Identification by shotgun sequencing, genomic organization, and functional analysis of a fourth arylsulfatase gene (ARSF) from the Xp22.3 region. Puca, A.A., Zollo, M., Repetto, M., Andolfi, G., Guffanti, A., Simon, G., Ballabio, A., Franco, B. Genomics (1997) [Pubmed]
  2. The A-site Finger in 23 S rRNA Acts as a Functional Attenuator for Translocation. Komoda, T., Sato, N.S., Phelps, S.S., Namba, N., Joseph, S., Suzuki, T. J. Biol. Chem. (2006) [Pubmed]
  3. Cryptic splice site usage in exon 7 of the human fibrinogen Bbeta-chain gene is regulated by a naturally silent SF2/ASF binding site within this exon. Spena, S., Tenchini, M.L., Buratti, E. RNA (2006) [Pubmed]
  4. Arylsulfatase D gene in Xp22.3 encodes two protein isoforms. Urbitsch, P., Salzer, M.J., Hirschmann, P., Vogt, P.H. DNA Cell Biol. (2000) [Pubmed]
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