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MeSH Review

Fetal Diseases

 
 
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Disease relevance of Fetal Diseases

 

Psychiatry related information on Fetal Diseases

 

High impact information on Fetal Diseases

 

Chemical compound and disease context of Fetal Diseases

 

Biological context of Fetal Diseases

 

Anatomical context of Fetal Diseases

 

Gene context of Fetal Diseases

  • Our results show that some cases of "thalidomide embryopathy" might be the result of SALL4 mutations, resulting in an increased risk for similarly affected offspring [27].
  • The aim of the present study was to investigate whether diabetic embryopathy may be associated with the inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) resulting from an excess of reactive oxygen species (ROS) in the embryo [28].
  • The aim of the present study was to investigate the putative involvement of different PKC isoforms (alpha, beta1, beta 2, gamma, delta, epsilon, and zeta) in the embryopathy of diabetic rat pregnancy [21].
  • Investigation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone for in vivo and iIn vitro murine embryopathy and embryonic ras mutations [29].
  • Embryopathies are increased in mutant mice deficient in the antioxidative enzyme glucose-6-phosphate dehydrogenase (G6PD), or by glutathione (GSH) depletion, or inhibition of GSH peroxidase or GSH reductase [30].
 

Analytical, diagnostic and therapeutic context of Fetal Diseases

References

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  21. Altered protein kinase C activation associated with rat embryonic dysmorphogenesis. Gäreskog, M., Wentzel, P. Pediatr. Res. (2004) [Pubmed]
  22. Retinoic acid-induced developmental defects are mediated by RARbeta/RXR heterodimers in the pharyngeal endoderm. Matt, N., Ghyselinck, N.B., Wendling, O., Chambon, P., Mark, M. Development (2003) [Pubmed]
  23. Increased synthesis of tumor necrosis factor-alpha in uterine explants from pregnant diabetic rats and in primary cultures of uterine cells in high glucose. Pampfer, S., Vanderheyden, I., De Hertogh, R. Diabetes (1997) [Pubmed]
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  26. Identification by shotgun sequencing, genomic organization, and functional analysis of a fourth arylsulfatase gene (ARSF) from the Xp22.3 region. Puca, A.A., Zollo, M., Repetto, M., Andolfi, G., Guffanti, A., Simon, G., Ballabio, A., Franco, B. Genomics (1997) [Pubmed]
  27. Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy. Kohlhase, J., Schubert, L., Liebers, M., Rauch, A., Becker, K., Mohammed, S.N., Newbury-Ecob, R., Reardon, W. J. Med. Genet. (2003) [Pubmed]
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  29. Investigation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone for in vivo and iIn vitro murine embryopathy and embryonic ras mutations. Winn, L.M., Kim, P.M., Wells, P.G. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  30. Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species. Wells, P.G., Bhuller, Y., Chen, C.S., Jeng, W., Kasapinovic, S., Kennedy, J.C., Kim, P.M., Laposa, R.R., McCallum, G.P., Nicol, C.J., Parman, T., Wiley, M.J., Wong, A.W. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
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  32. Severe cervical dysplasia and nasal cartilage calcification following prenatal warfarin exposure. Howe, A.M., Lipson, A.H., de Silva, M., Ouvrier, R., Webster, W.S. Am. J. Med. Genet. (1997) [Pubmed]
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