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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Fetal Diseases

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Disease relevance of Fetal Diseases


Psychiatry related information on Fetal Diseases


High impact information on Fetal Diseases


Chemical compound and disease context of Fetal Diseases


Biological context of Fetal Diseases


Anatomical context of Fetal Diseases


Gene context of Fetal Diseases

  • Our results show that some cases of "thalidomide embryopathy" might be the result of SALL4 mutations, resulting in an increased risk for similarly affected offspring [27].
  • The aim of the present study was to investigate whether diabetic embryopathy may be associated with the inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) resulting from an excess of reactive oxygen species (ROS) in the embryo [28].
  • The aim of the present study was to investigate the putative involvement of different PKC isoforms (alpha, beta1, beta 2, gamma, delta, epsilon, and zeta) in the embryopathy of diabetic rat pregnancy [21].
  • Investigation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone for in vivo and iIn vitro murine embryopathy and embryonic ras mutations [29].
  • Embryopathies are increased in mutant mice deficient in the antioxidative enzyme glucose-6-phosphate dehydrogenase (G6PD), or by glutathione (GSH) depletion, or inhibition of GSH peroxidase or GSH reductase [30].

Analytical, diagnostic and therapeutic context of Fetal Diseases


  1. Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves. Vitale, N., De Feo, M., De Santo, L.S., Pollice, A., Tedesco, N., Cotrufo, M. J. Am. Coll. Cardiol. (1999) [Pubmed]
  2. Toluene embryopathy: delineation of the phenotype and comparison with fetal alcohol syndrome. Pearson, M.A., Hoyme, H.E., Seaver, L.H., Rimsza, M.E. Pediatrics (1994) [Pubmed]
  3. Prenatal diagnosis of intrauterine infection with parvovirus B19 by the polymerase chain reaction technique. Török, T.J., Wang, Q.Y., Gary, G.W., Yang, C.F., Finch, T.M., Anderson, L.J. Clin. Infect. Dis. (1992) [Pubmed]
  4. Progressive and selective changes in neurotrophic factor expression and substance p axonal transport induced by perinatal diabetes: protective action of antioxidant treatment. Germani, E., Lesma, E., Di Giulio, A.M., Gorio, A. J. Neurosci. Res. (1999) [Pubmed]
  5. Vitamin K deficiency embryopathy: a phenocopy of the warfarin embryopathy due to a disorder of embryonic vitamin K metabolism. Menger, H., Lin, A.E., Toriello, H.V., Bernert, G., Spranger, J.W. Am. J. Med. Genet. (1997) [Pubmed]
  6. Pseudoaminopterin syndrome. Verloes, A., Bricteux, G., Koulischer, L. Am. J. Med. Genet. (1993) [Pubmed]
  7. Autism in thalidomide embryopathy: a population study. Strömland, K., Nordin, V., Miller, M., Akerström, B., Gillberg, C. Developmental medicine and child neurology. (1994) [Pubmed]
  8. A cluster of sulfatase genes on Xp22.3: mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy. Franco, B., Meroni, G., Parenti, G., Levilliers, J., Bernard, L., Gebbia, M., Cox, L., Maroteaux, P., Sheffield, L., Rappold, G.A. Cell (1995) [Pubmed]
  9. Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice. Balling, R., Mutter, G., Gruss, P., Kessel, M. Cell (1989) [Pubmed]
  10. IL-4-deficient Balb/c mice resist infection with Leishmania major. Kopf, M., Brombacher, F., Köhler, G., Kienzle, G., Widmann, K.H., Lefrang, K., Humborg, C., Ledermann, B., Solbach, W. J. Exp. Med. (1996) [Pubmed]
  11. Embryopathy in infant conceived one year after termination of maternal etretinate. Lammer, E.J. Lancet (1988) [Pubmed]
  12. Letter: Neural crest, limb development, and thalidomide embryopathy. Gardner, E., O'Rahilly, R. Lancet (1976) [Pubmed]
  13. The problem of cardiac valve prostheses, anticoagulants, and pregnancy. Salazar, E., Zajarias, A., Gutierrez, N., Iturbe, I. Circulation (1984) [Pubmed]
  14. Phosphoinositide metabolism in the developing conceptus. Effects of hyperglycemia and scyllo-inositol in rat embryo culture. Strieleman, P.J., Connors, M.A., Metzger, B.E. Diabetes (1992) [Pubmed]
  15. Significance of glutathione depletion and oxidative stress in early embryogenesis in glucose-induced rat embryo culture. Trocino, R.A., Akazawa, S., Ishibashi, M., Matsumoto, K., Matsuo, H., Yamamoto, H., Goto, S., Urata, Y., Kondo, T., Nagataki, S. Diabetes (1995) [Pubmed]
  16. Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment. Wentzel, P., Welsh, N., Eriksson, U.J. Diabetes (1999) [Pubmed]
  17. Teratogens and craniofacial malformations: relationships to cell death. Sulik, K.K., Cook, C.S., Webster, W.S. Development (1988) [Pubmed]
  18. Antisense evidence for nuclear factor-kappaB-dependent embryopathies initiated by phenytoin-enhanced oxidative stress. Kennedy, J.C., Memet, S., Wells, P.G. Mol. Pharmacol. (2004) [Pubmed]
  19. Oxygen-induced embryopathy and the significance of glutathione-dependent antioxidant system in the rat embryo during early organogenesis. Ishibashi, M., Akazawa, S., Sakamaki, H., Matsumoto, K., Yamasaki, H., Yamaguchi, Y., Goto, S., Urata, Y., Kondo, T., Nagataki, S. Free Radic. Biol. Med. (1997) [Pubmed]
  20. Cyclosporin A-induced embryopathy in embryo culture is mediated through inhibition of the arachidonic acid pathway. Uhing, M.R., Goldman, A.S., Goto, M.P. Proc. Soc. Exp. Biol. Med. (1993) [Pubmed]
  21. Altered protein kinase C activation associated with rat embryonic dysmorphogenesis. Gäreskog, M., Wentzel, P. Pediatr. Res. (2004) [Pubmed]
  22. Retinoic acid-induced developmental defects are mediated by RARbeta/RXR heterodimers in the pharyngeal endoderm. Matt, N., Ghyselinck, N.B., Wendling, O., Chambon, P., Mark, M. Development (2003) [Pubmed]
  23. Increased synthesis of tumor necrosis factor-alpha in uterine explants from pregnant diabetic rats and in primary cultures of uterine cells in high glucose. Pampfer, S., Vanderheyden, I., De Hertogh, R. Diabetes (1997) [Pubmed]
  24. Maternal and fetal sequelae of anticoagulation during pregnancy. Hall, J.G., Pauli, R.M., Wilson, K.M. Am. J. Med. (1980) [Pubmed]
  25. Phenytoin covalent binding and embryopathy in mouse embryos co-cultured with maternal hepatocytes from mouse, rat, and rabbit. Ozolins, T.R., Wiley, M.J., Wells, P.G. Biochem. Pharmacol. (1995) [Pubmed]
  26. Identification by shotgun sequencing, genomic organization, and functional analysis of a fourth arylsulfatase gene (ARSF) from the Xp22.3 region. Puca, A.A., Zollo, M., Repetto, M., Andolfi, G., Guffanti, A., Simon, G., Ballabio, A., Franco, B. Genomics (1997) [Pubmed]
  27. Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy. Kohlhase, J., Schubert, L., Liebers, M., Rauch, A., Becker, K., Mohammed, S.N., Newbury-Ecob, R., Reardon, W. J. Med. Genet. (2003) [Pubmed]
  28. Maternal diabetes in vivo and high glucose in vitro diminish GAPDH activity in rat embryos. Wentzel, P., Ejdesjö, A., Eriksson, U.J. Diabetes (2003) [Pubmed]
  29. Investigation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone for in vivo and iIn vitro murine embryopathy and embryonic ras mutations. Winn, L.M., Kim, P.M., Wells, P.G. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  30. Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species. Wells, P.G., Bhuller, Y., Chen, C.S., Jeng, W., Kasapinovic, S., Kennedy, J.C., Kim, P.M., Laposa, R.R., McCallum, G.P., Nicol, C.J., Parman, T., Wiley, M.J., Wong, A.W. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  31. Prenatal diagnosis of methotrexate embryopathy. Chapa, J.B., Hibbard, J.U., Weber, E.M., Abramowicz, J.S., Verp, M.S. Obstetrics and gynecology. (2003) [Pubmed]
  32. Severe cervical dysplasia and nasal cartilage calcification following prenatal warfarin exposure. Howe, A.M., Lipson, A.H., de Silva, M., Ouvrier, R., Webster, W.S. Am. J. Med. Genet. (1997) [Pubmed]
  33. Infantile hypertrophic pyloric stenosis after prenatal exposure to thalidomide. Schäfer, K.H., Kramer, M. Eur. J. Pediatr. (1987) [Pubmed]
  34. Electroencephalographic study of 137 patients with thalidomide embryopathy. Kanno, O. Jpn. J. Psychiatry Neurol. (1987) [Pubmed]
  35. Blepharoptosis and central nervous system abnormalities in combined valproate and hydantoin embryopathy. Gigantelli, J.W., Braddock, S.R., Johnson, L.N. Ophthalmic plastic and reconstructive surgery. (2000) [Pubmed]
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