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Gene Review:

Mst87F - Male-specific RNA 87F

Drosophila melanogaster

Synonyms: BEST:GH23081, CG17956, Dmel\CG17956, Male-specific sperm protein Mst87F, Mst, ...

Kuhn, R. et al., Callus, B.A. et al., Burfeind, P. et al., Schäfer, M. et al., Harvey, K.F. et al.

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High impact information on Mst87F

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis [1].
We have previously shown that Mst87F (previously called mst(3)g1-9), a gene which is exclusively expressed in the male germ line of Drosophila melanogaster, is subject to negative translational control [2].
We have isolated a cDNA from rat testis homologous to the Drosophila melanogaster gene mst(3)gl-9 by screening a rat testis cDNA library with mst(3)gl-9 and by direct PCR amplification of upstream sequences out of the cDNA library [3].
The Mst87F mRNA is transcribed in the primary spermatocytes, stored for three days and then subsequently translated in the post-elongation period of spermiogenesis [4].
In addition we have identified a conserved 12 base pair element within the 5' untranslated region (UTR) of each gene which is also found at an identical position in Mst87F and which has been demonstrated to be the structural element for translational control of Mst87F expression (Schäfer et al., 1990 EMBO J. 9, 4519-4525) [4].

Biological context of Mst87F

Coexpression of Mst and hSav led to phosphorylation of hSav and also increased its abundance [5].

References

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Harvey, K.F., Pfleger, C.M., Hariharan, I.K. Cell (2003) [Pubmed]
A conserved element in the leader mediates post-meiotic translation as well as cytoplasmic polyadenylation of a Drosophila spermatocyte mRNA. Schäfer, M., Kuhn, R., Bosse, F., Schäfer, U. EMBO J. (1990) [Pubmed]
Sequence and developmental expression of a mRNA encoding a putative protein of rat sperm outer dense fibers. Burfeind, P., Hoyer-Fender, S. Dev. Biol. (1991) [Pubmed]
A cluster of four genes selectively expressed in the male germ line of Drosophila melanogaster. Kuhn, R., Kuhn, C., Börsch, D., Glätzer, K.H., Schäfer, U., Schäfer, M. Mech. Dev. (1991) [Pubmed]
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. Callus, B.A., Verhagen, A.M., Vaux, D.L. FEBS J. (2006) [Pubmed]

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