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AHCY  -  adenosylhomocysteinase

Gallus gallus

 
 
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High impact information on AHCY

  • The changes in AdoMet and AdoHcy concentrations confirmed the inhibition of S-adenosylhomocysteine hydrolase or methionine adenosyltransferase, respectively, and the AdoMet/AdoHcy ratio was decreased in all cases, indicating reduced transmethylation [1].
  • After application of inhibitors of S-adenosylhomocysteine hydrolase and of methionine adenosyltransferase, a delay of anterior neuropore closure, comparable to that observed after Hcy treatment, was observed [1].
  • Eleven microorganisms, four plants, and major organs from the chicken, dog, rat and rabbit were assayed for the presence of S-adenosylhomocysteine hydrolase, S-adenosylhomocysteine nucleosidase, and S-ribosylhomocysteine-cleavage enzyme [2].
  • Of all the organs assayed in the vertebrates, the level of S-adenosylhomocysteine hydrolase was highest in liver, pancreas, and kidney, lower spleen and testis, and very low in brain and heart; In all systems tested, equilibrium of the hydrolase reaction always favored synthesis over hydrolysis [2].

References

  1. Inhibition of transmethylation disturbs neurulation in chick embryos. Afman, L.A., Blom, H.J., Drittij, M.J., Brouns, M.R., van Straaten, H.W. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  2. S-adenosylhomocysteine metabolism in various species. Walker, R.D., Duerre, J.A. Can. J. Biochem. (1975) [Pubmed]
 
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