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Gene Review

Ahcy  -  adenosylhomocysteinase

Rattus norvegicus

Synonyms: Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase
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Anatomical context of Ahcy


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Analytical, diagnostic and therapeutic context of Ahcy


  1. Deficiency of S-adenosylmethionine-homocysteine methyltransferase activity in hepatoma cells. Kuchino, Y., Yasuda, T., Nishimura, S. Cancer Res. (1977) [Pubmed]
  2. Mechanisms of elevation of adenosine levels in anoxic hepatocytes. Bontemps, F., Vincent, M.F., Van den Berghe, G. Biochem. J. (1993) [Pubmed]
  3. Expression of rat liver AdoHcy hydrolase in a Rhodobacter capsulatus ahcY mutant restores pigment formation and photosynthetic growth. Aksamit, R.R., Buggy, J.J., Bauer, C.E. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  4. Myocardial S-adenosylhomocysteine hydrolase is important for adenosine production during normoxia. Achterberg, P.W., de Tombe, P.P., Harmsen, E., de Jong, J.W. Biochim. Biophys. Acta (1985) [Pubmed]
  5. Induction by fungal elicitor of S-adenosyl-L-methionine synthetase and S-adenosyl-L-homocysteine hydrolase mRNAs in cultured cells and leaves of Petroselinum crispum. Kawalleck, P., Plesch, G., Hahlbrock, K., Somssich, I.E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. Amino acid sequence of S-adenosyl-L-homocysteine hydrolase from rat liver as derived from the cDNA sequence. Ogawa, H., Gomi, T., Mueckler, M.M., Fujioka, M., Backlund, P.S., Aksamit, R.R., Unson, C.G., Cantoni, G.L. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  7. Inactivation and reactivation of intracellular S-adenosylhomocysteinase in the presence of nucleoside analogues in rat hepatocytes. Schanche, J.S., Schanche, T., Ueland, P.M., Montgomery, J.A. Cancer Res. (1984) [Pubmed]
  8. Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190. Takata, Y., Yamada, T., Huang, Y., Komoto, J., Gomi, T., Ogawa, H., Fujioka, M., Takusagawa, F. J. Biol. Chem. (2002) [Pubmed]
  9. Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine. Huang, Y., Komoto, J., Takata, Y., Powell, D.R., Gomi, T., Ogawa, H., Fujioka, M., Takusagawa, F. J. Biol. Chem. (2002) [Pubmed]
  10. Crystal structure of S-adenosylhomocysteine hydrolase from rat liver. Hu, Y., Komoto, J., Huang, Y., Gomi, T., Ogawa, H., Takata, Y., Fujioka, M., Takusagawa, F. Biochemistry (1999) [Pubmed]
  11. The gene and pseudogenes of rat S-adenosyl-L-homocysteine hydrolase. Merta, A., Aksamit, R.R., Kasir, J., Cantoni, G.L. Eur. J. Biochem. (1995) [Pubmed]
  12. Neplanocin A. Actions on S-adenosylhomocysteine hydrolase and on hormone synthesis by GH4C1 cells. Wolfson, G., Chisholm, J., Tashjian, A.H., Fish, S., Abeles, R.H. J. Biol. Chem. (1986) [Pubmed]
  13. Regional and subcellular distribution of S-adenosylhomocysteine hydrolase in the adult rat brain. Broch, O.J., Ueland, P.M. J. Neurochem. (1980) [Pubmed]
  14. Protein carboxyl methylation in synaptic membrane of rat brain: the possible presence of adenosine-bound S-adenosyl-L-homocysteine hydrolase in the membrane. Miyake, M., Innami, T. J. Neurochem. (1987) [Pubmed]
  15. Age-dependent variations of cell response to oxidative stress: proteomic approach to protein expression and phosphorylation. Miura, Y., Kano, M., Abe, K., Urano, S., Suzuki, S., Toda, T. Electrophoresis (2005) [Pubmed]
  16. NGF promotes copper accumulation required for optimum neurite outgrowth and protein methylation. Birkaya, B., Aletta, J.M. J. Neurobiol. (2005) [Pubmed]
  17. S-adenosylhomocysteinase from rat liver. Amino acid sequences of the peptides containing active site cysteine residues modified by treatment with 5'-p-fluorosulfonylbenzoyladenosine. Gomi, T., Ogawa, H., Fujioka, M. J. Biol. Chem. (1986) [Pubmed]
  18. Effects of site-directed mutagenesis on structure and function of recombinant rat liver S-adenosylhomocysteine hydrolase. Crystal structure of D244E mutant enzyme. Komoto, J., Huang, Y., Gomi, T., Ogawa, H., Takata, Y., Fujioka, M., Takusagawa, F. J. Biol. Chem. (2000) [Pubmed]
  19. Isolation, cloning and characterization of a low-molecular-mass purine nucleoside- and nucleotide-binding protein. Gilmour, J., Liang, N., Lowenstein, J.M. Biochem. J. (1997) [Pubmed]
  20. Effect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5'-isobutylthioadenosine. Della Ragione, F., Pegg, A.E. Biochem. J. (1983) [Pubmed]
  21. Regulation of biogenic amine methyltransferases by glucocorticoids via S-adenosylmethionine and its metabolizing enzymes, methionine adenosyltransferase and S-adenosylhomocysteine hydrolase. Wong, D.L., Hayashi, R.J., Ciaranello, R.D. Brain Res. (1985) [Pubmed]
  22. Affinity-chromatographic purification of S-adenosyl-L-homocysteine hydrolase. Some properties of the enzyme from rat liver. Kajander, E.O., Raina, A.M. Biochem. J. (1981) [Pubmed]
  23. Trypanosoma cruzi: molecular cloning and characterization of the S-adenosylhomocysteine hydrolase. Parker, N.B., Yang, X., Hanke, J., Mason, K.A., Schowen, R.L., Borchardt, R.T., Yin, D.H. Exp. Parasitol. (2003) [Pubmed]
  24. Effect of vitamin B6 deficiency on the synthesis and accumulation of S-adenosylhomocysteine and S-adenosylmethionine in rat tissues. Nguyen, T.T., Hayakawa, T., Tsuge, H. J. Nutr. Sci. Vitaminol. (2001) [Pubmed]
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