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Gene Review

MEE58  -  adenosylhomocysteinase 1

Arabidopsis thaliana

Synonyms: ATSAHH1, DL3010W, EMB1395, EMBRYO DEFECTIVE 1395, FCAALL.35, ...
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High impact information on HOG1


Biological context of HOG1


Associations of HOG1 with chemical compounds

  • The insertion was identified to be in the intergenic area between loci At4G13940 and At4G13930, coding for SAHH (S-Adenosyl-l-Homocysteine Hydrolase) and SHMT (Serine Hydroxy Methyl Transferase) genes, respectively [7].
  • Because SAHH activity is inhibited by its products, we propose that ADK is not a stress-responsive enzyme per se, but plays a pivotal role in sustaining transmethylation reactions in general by serving as a coarse metabolic control to reduce the cellular concentration of free adenosine [3].

Other interactions of HOG1


  1. The Arabidopsis HOMOLOGY-DEPENDENT GENE SILENCING1 gene codes for an S-adenosyl-L-homocysteine hydrolase required for DNA methylation-dependent gene silencing. Rocha, P.S., Sheikh, M., Melchiorre, R., Fagard, M., Boutet, S., Loach, R., Moffatt, B., Wagner, C., Vaucheret, H., Furner, I. Plant Cell (2005) [Pubmed]
  2. Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation. Moffatt, B.A., Stevens, Y.Y., Allen, M.S., Snider, J.D., Pereira, L.A., Todorova, M.I., Summers, P.S., Weretilnyk, E.A., Martin-McCaffrey, L., Wagner, C. Plant Physiol. (2002) [Pubmed]
  3. Maintaining methylation activities during salt stress. The involvement of adenosine kinase. Weretilnyk, E.A., Alexander, K.J., Drebenstedt, M., Snider, J.D., Summers, P.S., Moffatt, B.A. Plant Physiol. (2001) [Pubmed]
  4. Gene silencing and homology-dependent gene silencing in Arabidopsis: genetic modifiers and DNA methylation. Furner, I.J., Sheikh, M.A., Collett, C.E. Genetics (1998) [Pubmed]
  5. Genetics of homology-dependent gene silencing in Arabidopsis; a role for methylation. Davies, G.J., Sheikh, M.A., Ratcliffe, O.J., Coupland, G., Furner, I.J. Plant J. (1997) [Pubmed]
  6. Organization, not duplication, triggers silencing in a complex transgene locus in rice. Yang, G., Lee, Y.H., Jiang, Y., Kumpatla, S.P., Hall, T.C. Plant Mol. Biol. (2005) [Pubmed]
  7. T-DNA tagging and characterization of a cryptic root-specific promoter in Arabidopsis. Sivanandan, C., Sujatha, T.P., Prasad, A.M., Resminath, R., Thakare, D.R., Bhat, S.R., Srinivasan, n.u.l.l. Biochim. Biophys. Acta (2005) [Pubmed]
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