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Gene Review

Ahcy  -  S-adenosylhomocysteine hydrolase

Mus musculus

Synonyms: AA987153, AL024110, Adenosylhomocysteinase, AdoHcyase, CUBP, ...
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Disease relevance of Ahcy


High impact information on Ahcy


Chemical compound and disease context of Ahcy


Biological context of Ahcy


Anatomical context of Ahcy


Associations of Ahcy with chemical compounds


Other interactions of Ahcy


Analytical, diagnostic and therapeutic context of Ahcy


  1. Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells. Borchardt, R.T., Keller, B.T., Patel-Thombre, U. J. Biol. Chem. (1984) [Pubmed]
  2. Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency. Blackburn, M.R., Datta, S.K., Kellems, R.E. J. Biol. Chem. (1998) [Pubmed]
  3. Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities. Tseng, C.K., Marquez, V.E., Fuller, R.W., Goldstein, B.M., Haines, D.R., McPherson, H., Parsons, J.L., Shannon, W.M., Arnett, G., Hollingshead, M. J. Med. Chem. (1989) [Pubmed]
  4. A reversible s-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activation. Fu, Y.F., Zhu, Y.N., Ni, J., Zhong, X.G., Tang, W., Re, Y.D., Shi, L.P., Wan, J., Yang, Y.F., Yuan, C., Nan, F.J., Lawson, B.R., Zuo, J.P. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  5. S-Adenosyl-L-homocysteine hydrolase inhibitor mediates immunosuppressive effects in vivo: suppression of delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide-induced arthritis. Saso, Y., Conner, E.M., Teegarden, B.R., Yuan, C.S. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  6. CD28 costimulatory signal induces protein arginine methylation in T cells. Blanchet, F., Cardona, A., Letimier, F.A., Hershfield, M.S., Acuto, O. J. Exp. Med. (2005) [Pubmed]
  7. Complementary change in cis determinants and trans factors in the evolution of an mRNP stability complex. Wang, X., Liebhaber, S.A. EMBO J. (1996) [Pubmed]
  8. The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene. Miller, M.W., Duhl, D.M., Winkes, B.M., Arredondo-Vega, F., Saxon, P.J., Wolff, G.L., Epstein, C.J., Hershfield, M.S., Barsh, G.S. EMBO J. (1994) [Pubmed]
  9. 3-Deazaadenosine-induced disorganization of macrophage microfilaments. Stopford, C.R., Wolberg, G., Prus, K.L., Reynolds-Vaughn, R., Zimmerman, T.P. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  10. Selection and characterization of a murine lymphoid cell line partially deficient in S-adenosylhomocysteine hydrolase. Kamatani, N., Willis, E.H., Carson, D.A. Biochim. Biophys. Acta (1983) [Pubmed]
  11. Mapping of the structural gene for S-adenosyl homocysteine hydrolase to mouse chromosome 2, and related sequences to chromosomes 8 and X. Pilz, A., Le Tissier, P., Moseley, H., Peters, J., Abbott, C. Mamm. Genome (1992) [Pubmed]
  12. Identification of a major hepatic copper binding protein as S-adenosylhomocysteine hydrolase. Bethin, K.E., Petrovic, N., Ettinger, M.J. J. Biol. Chem. (1995) [Pubmed]
  13. S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance. Dwivedi, R.S., Wang, L.J., Mirkin, B.L. Cancer Res. (1999) [Pubmed]
  14. E1 mice epilepsy shows genetic polymorphism for S-Adenosyl-L-homocysteine hydrolase. Mita, T., Kawazu, I., Hirano, H., Ohmori, O., Janjua, N., Shibata, K. Neurochem. Int. (2001) [Pubmed]
  15. Purification and properties of a self-associating, 50-kDa copper-binding protein from brindled mouse livers. Seo, H.C., Ettinger, M.J. J. Biol. Chem. (1993) [Pubmed]
  16. Selective inhibition of T cell activation by an inhibitor of S-adenosyl-L-homocysteine hydrolase. Wolos, J.A., Frondorf, K.A., Davis, G.F., Jarvi, E.T., McCarthy, J.R., Bowlin, T.L. J. Immunol. (1993) [Pubmed]
  17. 3-Deazaadenosine. S-adenosylhomocysteine hydrolase-independent mechanism of action in mouse lymphocytes. Zimmerman, T.P., Iannone, M., Wolberg, G. J. Biol. Chem. (1984) [Pubmed]
  18. Regulatory role for the immune complex in modulation of phagocytosis by 3-deazaadenosine. Medzihradsky, J.L. J. Immunol. (1984) [Pubmed]
  19. Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice. Farrar, C., Clarke, S. J. Biol. Chem. (2002) [Pubmed]
  20. Effect of 2'-deoxycoformycin infusion on S-adenosylhomocysteine hydrolase and the amount of S-adenosylhomocysteine and related compounds in tissues of mice. Helland, S., Ueland, P.M. Cancer Res. (1983) [Pubmed]
  21. S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in various tissues of mice given injections of 9-beta-D-arabinofuranosyladenine. Helland, S., Ueland, P.M. Cancer Res. (1983) [Pubmed]
  22. Biosynthesis of S-N6-methyladenosylhomocysteine, an inhibitor of RNA methyltransferases. Hoffman, J.L. J. Biol. Chem. (1978) [Pubmed]
  23. Impaired germinal center maturation in adenosine deaminase deficiency. Aldrich, M.B., Chen, W., Blackburn, M.R., Martinez-Valdez, H., Datta, S.K., Kellems, R.E. J. Immunol. (2003) [Pubmed]
  24. Effect of adenosine analogues on protein carboxylmethyltransferase, S-adenosylhomocysteine hydrolase, and ribonucleotide reductase activity in murine neuroblastoma cells. O'Dea, R.F., Mirkin, B.L., Hogenkamp, H.P., Barten, D.M. Cancer Res. (1987) [Pubmed]
  25. 3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice. Ovechkin, A.V., Tyagi, N., Sen, U., Lominadze, D., Steed, M.M., Moshal, K.S., Tyagi, S.C. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  26. Immunosuppression mediated by an inhibitor of S-adenosyl-L-homocysteine hydrolase. Prevention and treatment of collagen-induced arthritis. Wolos, J.A., Frondorf, K.A., Esser, R.E. J. Immunol. (1993) [Pubmed]
  27. Copper binding to mouse liver S-adenosylhomocysteine hydrolase and the effects of copper on its levels. Bethin, K.E., Cimato, T.R., Ettinger, M.J. J. Biol. Chem. (1995) [Pubmed]
  28. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase. Borcherding, D.R., Narayanan, S., Hasobe, M., McKee, J.G., Keller, B.T., Borchardt, R.T. J. Med. Chem. (1988) [Pubmed]
  29. Antiviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse model. Huggins, J., Zhang, Z.X., Bray, M. J. Infect. Dis. (1999) [Pubmed]
  30. Inhibition of S-adenosyl-L-homocysteine hydrolase induces immunosuppression. Wu, Q.L., Fu, Y.F., Zhou, W.L., Wang, J.X., Feng, Y.H., Liu, J., Xu, J.Y., He, P.L., Zhou, R., Tang, W., Wang, G.F., Zhou, Y., Yang, Y.F., Ding, J., Li, X.Y., Chen, X.R., Yuan, C., Lawson, B.R., Zuo, J.P. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
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