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Gene Review:

Rbf2 - Retinoblastoma-family protein 2

Drosophila melanogaster

Synonyms: CG5083, Dmel\CG5083, RB, RBF2, rbf2

Ullah, Z. et al., Stevaux, O. et al., Taylor-Harding, B. et al., Stevaux, O. et al.

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Disease relevance of Rbf2

Similar to their human counterparts, the Drosophila Rbf1 and Rbf2 Retinoblastoma family members control cell cycle and developmentally regulated gene expression [1].

High impact information on Rbf2

We find that RBF2-mediated repression requires dE2F2 [2].
More over, RBF2 and dE2F2 act synergistically to antagonize dE2F1-mediated activation, and they co-operate to block S phase progression in transgenic animals [2].
Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2 [2].
The targeted knockdown of individual CSN subunits leads to diminished Rbf1 and Rbf2 levels and to altered cell cycle progression [1].
We show here that the developmentally regulated COP9 signalosome (CSN) physically interacts with Rbf2 during embryogenesis [1].

Biological context of Rbf2

With RNA interference (RNAi), we depleted potential corepressors and looked for the elevated expression of groups of E2F target genes that are known to be directly regulated by RBF1 and RBF2 [3].

Physical interactions of Rbf2

In contrast, RBF2 binds exclusively to dE2F2, a form of E2F that functions as a transcriptional repressor [2].

Other interactions of Rbf2

Here we find that RBF2 functions in concert with dE2F2 in vivo to repress the expression of differentiation markers in ovaries and embryos where RBF2 is highly expressed [4].

References

Retinoblastoma Protein Regulation by the COP9 Signalosome. Ullah, Z., Buckley, M.S., Arnosti, D.N., Henry, R.W. Mol. Biol. Cell (2007) [Pubmed]
Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. Stevaux, O., Dimova, D., Frolov, M.V., Taylor-Harding, B., Morris, E., Dyson, N. EMBO J. (2002) [Pubmed]
p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes. Taylor-Harding, B., Binné, U.K., Korenjak, M., Brehm, A., Dyson, N.J. Mol. Cell. Biol. (2004) [Pubmed]
Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes. Stevaux, O., Dimova, D.K., Ji, J.Y., Moon, N.S., Frolov, M.V., Dyson, N.J. Cell Cycle (2005) [Pubmed]

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