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Gene Review

E2f2  -  E2F transcription factor 2

Drosophila melanogaster

Synonyms: CG1071, Dmel\CG1071, E2F, E2F-like transcription factor E2F2, E2F2, ...
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Disease relevance of E2f2


High impact information on E2f2

  • These complexes contain RBF, E2F, and Myb-interacting proteins that have previously been shown to control developmentally regulated patterns of DNA replication in follicle cells [4].
  • The retinoblastoma tumor suppressor protein (pRb) regulates gene transcription by binding E2F transcription factors. pRb can recruit several repressor complexes to E2F bound promoters; however, native pRb repressor complexes have not been isolated [4].
  • The complexes localize to transcriptionally silent sites on polytene chromosomes and mediate stable repression of a specific set of E2F targets that have sex- and differentiation-specific expression patterns [4].
  • These and other data now link together the Myb and E2F2 complexes in higher-order assembly to specific chromosomal sites for the regulation of transcription [5].
  • The implication of these results is that cells containing dE2F2 require dE2F1 to either prevent, or reverse, dE2F-mediated repression [6].

Biological context of E2f2


Anatomical context of E2f2


Physical interactions of E2f2

  • In contrast, RBF2 binds exclusively to dE2F2, a form of E2F that functions as a transcriptional repressor [11].

Other interactions of E2f2

  • These differences correlate with differences in the magnitude of the replication defects in follicle cells, which attain an inappropriate 32C DNA content in both Rbf1 and Dp mutants but not in E2f2 mutants [7].
  • For some genes the magnitude of this transcriptional derepression is greater in Rbf1 than in E2f2 mutants [7].
  • RT-PCR analyses of RNA purified from E2f2 mutant follicle cells indicate an increase in the level of Orc5 mRNA relative to wild type [2].
  • G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression [6].
  • We find that RBF2-mediated repression requires dE2F2 [11].

Analytical, diagnostic and therapeutic context of E2f2

  • Here we show by both reverse transcription-PCR and DNA microarray analysis that the transcripts of prereplication complex (pre-RC) genes are elevated compared to the wild type in E2f2, Dp, and Rbf1 mutant follicle cells [7].


  1. p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes. Taylor-Harding, B., Binné, U.K., Korenjak, M., Brehm, A., Dyson, N.J. Mol. Cell. Biol. (2004) [Pubmed]
  2. Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. Cayirlioglu, P., Bonnette, P.C., Dickson, M.R., Duronio, R.J. Development (2001) [Pubmed]
  3. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. Veal, E., Eisenstein, M., Tseng, Z.H., Gill, G. Mol. Cell. Biol. (1998) [Pubmed]
  4. Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Korenjak, M., Taylor-Harding, B., Binné, U.K., Satterlee, J.S., Stevaux, O., Aasland, R., White-Cooper, H., Dyson, N., Brehm, A. Cell (2004) [Pubmed]
  5. Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Lewis, P.W., Beall, E.L., Fleischer, T.C., Georlette, D., Link, A.J., Botchan, M.R. Genes Dev. (2004) [Pubmed]
  6. G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression. Frolov, M.V., Stevaux, O., Moon, N.S., Dimova, D., Kwon, E.J., Morris, E.J., Dyson, N.J. Genes Dev. (2003) [Pubmed]
  7. Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. Cayirlioglu, P., Ward, W.O., Silver Key, S.C., Duronio, R.J. Mol. Cell. Biol. (2003) [Pubmed]
  8. Repression of fibroblast growth factor receptor 1 gene expression by E2F4 in skeletal muscle cells. Parakati, R., Dimario, J.X. Dev. Dyn. (2005) [Pubmed]
  9. Functional Identification of Api5 as a Suppressor of E2F-Dependent Apoptosis In Vivo. Morris, E.J., Michaud, W.A., Ji, J.Y., Moon, N.S., Rocco, J.W., Dyson, N.J. PLoS Genet. (2006) [Pubmed]
  10. Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. de la Luna, S., Allen, K.E., Mason, S.L., La Thangue, N.B. EMBO J. (1999) [Pubmed]
  11. Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. Stevaux, O., Dimova, D., Frolov, M.V., Taylor-Harding, B., Morris, E., Dyson, N. EMBO J. (2002) [Pubmed]
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