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Gene Review:

NPPC - natriuretic peptide C

Gallus gallus

Arimura, J.J. et al., Ishizaka, Y. et al., Holthues, H. et al., Dong, S.S. et al., Yoshihara, A. et al., et al.

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High impact information on LOC419487

Porcine CNP22, C-type natriuretic peptide, and the fragment C-ANF exhibited undefined secondary structure in the presence of 40% HFIP/phosphate buffer [1].
The effect of light was also counteracted by the nitric oxide donor sodium nitroprusside and C-type natriuretic peptide, both of which increase cGMP levels, and by the calcium channel agonist Bay K 8644, which prevents the cGMP-decrease-induced closure of cGMP-gated calcium channels [2].
However, C-type natriuretic peptide did not increase cGMP in purified osteoclasts [3].
C-type natriuretic peptide drives a membrane guanylate cyclase, and increased cGMP production in mixed bone cells [3].
Production of CNP in THP-1 cells suggests that CNP also functions as a local regulator in the blood cell-vascular system, although CNP has previously been recognized as a neuropeptide functioning in the central nervous system [4].

Biological context of LOC419487

Frog CNP may participate in the central control of body fluid homeostasis, since its tissue concentration is high in brain [5].

Anatomical context of LOC419487

Chicken CNP also elicits pharmacological effects highly similar to porcine CNP, suggesting that CNP functions as a neuropeptide in the chicken central nervous system [6].
Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1 [4].

Analytical, diagnostic and therapeutic context of LOC419487

Using a radioimmunoassay system for porcine CNP, we found a significant concentration of immunoreactive (ir-) CNP in chicken brain, from which a new peptide was isolated [6].
Isolation and sequence determination of frog C-type natriuretic peptide [5].

References

Evaluation of conformational and binding characteristics of various natriuretic peptides and related analogs. Mimeault, M., De Léan, A., Lafleur, M., Bonenfant, D., Fournier, A. Biochemistry (1995) [Pubmed]
The phototransduction cascade in the isolated chick pineal gland revisited. Holthues, H., Vollrath, L. Brain Res. (2004) [Pubmed]
Nitric oxide regulation of cGMP production in osteoclasts. Dong, S.S., Williams, J.P., Jordan, S.E., Cornwell, T., Blair, H.C. J. Cell. Biochem. (1999) [Pubmed]
Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1. Ishizaka, Y., Kangawa, K., Minamino, N., Ishii, K., Takano, S., Eto, T., Matsuo, H. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
Isolation and sequence determination of frog C-type natriuretic peptide. Yoshihara, A., Kozawa, H., Minamino, N., Kangawa, K., Matsuo, H. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
Isolation and identification of C-type natriuretic peptide in chicken brain. Arimura, J.J., Minamino, N., Kangawa, K., Matsuo, H. Biochem. Biophys. Res. Commun. (1991) [Pubmed]

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